Publication: Associations of HLA class II alleles with pulmonary tuberculosis in thais
Issued Date
2002-10-29
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ISSN
09607420
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2-s2.0-0036401581
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Mahidol University
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SCOPUS
Bibliographic Citation
European Journal of Immunogenetics. Vol.29, No.5 (2002), 431-434
Suggested Citation
S. Vejbaesya, N. Chierakul, K. Luangtrakool, D. Srinak, H. A.F. Stephens Associations of HLA class II alleles with pulmonary tuberculosis in thais. European Journal of Immunogenetics. Vol.29, No.5 (2002), 431-434. doi:10.1046/j.1365-2370.2002.00352.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/20035
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Title
Associations of HLA class II alleles with pulmonary tuberculosis in thais
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Abstract
Tuberculosis is an important infectious disease in Thailand. Susceptibility to tuberculosis is influenced not only by the environment but also by host genetic factors. In this study, we investigated HLA alleles in 82 patients with tuberculosis from Bangkok and in 160 normal controls. HLA-DRB1, DQA1 and DQB1 genotyping was performed by the PCR-SSO method. The frequency of HLA-DQB1*0502 was increased in tuberculosis patients compared to the normal controls (P = 0.01, OR = 2.06). In contrast, the frequencies of DQA1*0601 and DQB1*0301 were decreased in tuberculosis patients compared to the controls (P = 0.02 and P = 0.01, respectively). Our results suggest that HLA-DQB1*0502 may be involved in the development of pulmonary tuberculosis, whereas HLA-DQA1*0601 and DQB1*0301 may be associated with protection against tuberculosis.