Publication: Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f.
Issued Date
2007-05-04
Resource Type
ISSN
03788741
Other identifier(s)
2-s2.0-34047249406
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Ethnopharmacology. Vol.111, No.2 (2007), 335-340
Suggested Citation
Ampai Panthong, Pinpaka Norkaew, Duangta Kanjanapothi, Tawat Taesotikul, Natthinee Anantachoke, Vichai Reutrakul Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f.. Journal of Ethnopharmacology. Vol.111, No.2 (2007), 335-340. doi:10.1016/j.jep.2006.11.038 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25104
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Anti-inflammatory, analgesic and antipyretic activities of the extract of gamboge from Garcinia hanburyi Hook f.
Other Contributor(s)
Abstract
In Thai floklore medicine, gamboge, the yellow gum-resin secreted from Garcinia hanburyi, is used for infected wound, pain and edema The ethyl acetate extract from Garcinia hanburyi (GH5763) was assessed for anti-inflammatory, analgesic and antipyretic activities using experimental animal models. It was found that GH5763 possessed inhibitory activity on acute phase of inflammation as seen in ethyl phenylpropiolate-induced ear edema and carrageenin-induced hind paw edema in rats. However, GH5763 did not elicit any inhibitory effect on arachidonic acid-induced hind paw edema. In subchronic inflammatory model, GH5763 provoked a significant reduction of both transudative and proliferative phase when tested on cotton pellet-induced granuloma model. GH5763 also reduced the alkaline phosphatase activity in serum of rats in this animal model. In the analgesic test, GH5763 elicited inhibitory activity on acetic acid-induced writhing response and on both the early and the late phase of formalin test. Moreover, GH5763 also possessed an excellent antipyretic effect when tested in yeast-induced hyperthermic rats. It is postulated that the anti-inflammatory, analgesic and antipyretic activities of GH5763 are caused by the inhibition of the prostaglandin biosynthesis. © 2007.