Publication: Impact of long-term systemic treatment for psoriasis on liver disease in psoriasis patients with coexisting hepatitis B virus infection
Issued Date
2020-01-01
Resource Type
ISSN
15298019
13960296
13960296
Other identifier(s)
2-s2.0-85090445551
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Dermatologic Therapy. (2020)
Suggested Citation
Leena Chularojanamontri, Supot Nimanong, Chanisada Wongpraparut, Narumol Silpa-Archa, Chayada Chaiyabutr, Norramon Charoenpipatsin Impact of long-term systemic treatment for psoriasis on liver disease in psoriasis patients with coexisting hepatitis B virus infection. Dermatologic Therapy. (2020). doi:10.1111/dth.14008 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59254
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Impact of long-term systemic treatment for psoriasis on liver disease in psoriasis patients with coexisting hepatitis B virus infection
Other Contributor(s)
Abstract
© 2020 Wiley Periodicals LLC. Continuously updated information is helpful for evaluating the safety of long-term systemic drug use in psoriasis patients with concomitant hepatitis B virus (HBV) infection. To investigate the impact of long-term systemic treatment for psoriasis on liver disease in psoriasis patients with HBV infection. Data of patients during 10-year period were recorded and analyzed. Sixty-six patients (46 males and 20 females) with a mean age of 58.5 ± 13.1 years were recruited. Our study estimated that the 5-year cumulative risks of developing cirrhosis and HCC were 30% and 5%, respectively, in patients receiving systemic treatments for psoriasis. Risks of cirrhosis and HCC were not significantly different between systemic and topical treatment groups. Thirty patients were prescribed systemic treatments (acitretin, methotrexate, ciclosporin, and anti-tumor necrosis factors). Three HBsAg+ patients developed viral reactivation (two patients with methotrexate and one patient with ciclosporin). The effects of systemic treatments for psoriasis on liver outcome in patients with coexisting HBV infection are needed to be determined. HBsAg+ patients are more likely to develop viral reactivation during systemic treatment for psoriasis than HBsAg− patients. Monitoring of liver enzymes and HBV DNA every 3 months is recommended during treatment and for 6 to 12 months after drug discontinuation.