Publication:
Silver-mediated decarboxylative fluorination of paraconic acids: A direct entry to β-fluorinated γ-butyrolactones

Issued Date

2015-05-01

Resource Type

Article

ISSN

10990690
1434193X

DOI

10.1002/ejoc.201500023

Other identifier(s)

2-s2.0-84928036476

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

European Journal of Organic Chemistry. Vol.2015, No.13 (2015), 2879-2888

Suggested Citation

Supasorn Phae-Nok, Darunee Soorukram, Chutima Kuhakarn, Vichai Reutrakul, Manat Pohmakotr Silver-mediated decarboxylative fluorination of paraconic acids: A direct entry to β-fluorinated γ-butyrolactones. European Journal of Organic Chemistry. Vol.2015, No.13 (2015), 2879-2888. doi:10.1002/ejoc.201500023 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/35750

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Title

Silver-mediated decarboxylative fluorination of paraconic acids: A direct entry to β-fluorinated γ-butyrolactones

Author(s)

Supasorn Phae-Nok
 Darunee Soorukram
 Chutima Kuhakarn
 Vichai Reutrakul
 Manat Pohmakotr

Other Contributor(s)

Mahidol University

Abstract

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. The silver(I)-mediated decarboxylative fluorination of paraconic acids using Selectfluor<sup>®</sup> as a fluorine source is reported. Readily available paraconic acids undergo decarboxylative fluorination with Selectfluor<sup>®</sup> mediated by AgNO<inf>3</inf> to give the corresponding β-fluorinated γ-butyrolactones in moderate to good yields. This approach serves as a direct and site-selective strategy for the introduction of a fluorine atom at the β position of γ-butyrolactone cores. The fluorinated products are synthetically useful scaffolds for organic synthesis.

Keyword(s)

Chemistry

Availability

URI

https://repository.li.mahidol.ac.th/handle/123456789/35750

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Scopus 2011-2015