Publication: Relationship between α-MSH, soluble leptin receptor, MC4R polymorphism and BMI in Thai children and adolescents
Issued Date
2010-01-01
Resource Type
ISSN
18795404
18795390
18795390
Other identifier(s)
2-s2.0-85021652008
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Pediatric Biochemistry. Vol.1, No.4 (2010), 303-308
Suggested Citation
Rungsunn Tungtrongchitr, Benjaluck Phonrat, Uruwan Yamborisut, Supaluk Popruk, Anchalee Tungtrongchitr Relationship between α-MSH, soluble leptin receptor, MC4R polymorphism and BMI in Thai children and adolescents. Journal of Pediatric Biochemistry. Vol.1, No.4 (2010), 303-308. doi:10.1055/s-0036-1586389 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/29803
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Relationship between α-MSH, soluble leptin receptor, MC4R polymorphism and BMI in Thai children and adolescents
Other Contributor(s)
Abstract
© 2010/2011 - IOS Press and the authors. All rights reserved. In order to evaluate the mechanism of disturbance of melanocortin signaling in different groups of Thai children and adolescents classified according to body mass index (BMI) percentile for age by The Centers for Disease Control and Prevention (CDC) growth charts, and α-melanocortin stimulating hormone (α-MSH), soluble leptin receptor and melanocortin -4 receptor (MC4R) polymorphism were studied. 149 male and 127 female children and adolescent Thai subjects with age range between 5-19 years were selected. Statistically significant difference of serum leptin receptor concentration between under weight (< 5th percentile), possible at risk for underweight (between 5th and 15th percentile), probably healthy (between 15th and 85th percentile); at risk for overweight (between the 85th and 95th percentile) and overweight (over the 95th percentile) were found. The levels of α-MSH were not significantly different when comparing the groups. Heterozygous of MC4R polymorphism (Val103Ile) were found in underweight, possible at risk for underweight and probably healthy group which might have been the cause of lower BMI for age even they have had normal serum α-MSH concentration. Using the logistic regression analysis, the group of risk for being overweight and overweight was statistically significant with α-MSH. This study supported a positive correlation between α-MSH and BMI with ages of Thai children and adolescents group.