Publication: Resveratrol tetramers from Vatica diospyroides
Issued Date
1999-09-17
Resource Type
ISSN
00223263
Other identifier(s)
2-s2.0-0033578950
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Organic Chemistry. Vol.64, No.19 (1999), 6976-6983
Suggested Citation
Eun Kyoung Seo, Heebyung Chai, Howard L. Constant, Thawatchai Santisuk, Vichai Reutrakul, Christopher W W Beecher, Norman R. Farnsworth, Geoffrey A. Cordell, John M. Pezzuto, A. Douglas Kinghorn Resveratrol tetramers from Vatica diospyroides. Journal of Organic Chemistry. Vol.64, No.19 (1999), 6976-6983. doi:10.1021/jo9902087 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/25379
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Title
Resveratrol tetramers from Vatica diospyroides
Abstract
Vatdiospyroidol (1), a novel cytotoxic resveratrol tetramer, was isolated from the stems of Vatica diospyroides Sym. (Dipterocarpaceae) by bioassay-guided fractionation monitored with a human oral epidermoid carcinoma (KB) cell line. Another novel resveratrol tetramer, vaticaphenol A (2), was obtained as a noncytotoxic constituent, along with the known compounds, bergenin, betulin, betulinic acid, mangiferonic acid, and (E)- resveratrol 3-O-β-D-glucopyranoside. The structures of compounds 1 and 2 were elucidated by spectral analysis, including 1D and 2D NMR experiments, and by molecular modeling.