Publication:
Effect of pyrexia in the formation of intraerythrocytic inclusion bodies and vacuoles in haemolytic crisis of haemoglobin H disease

Issued Date

1994-01-01

Resource Type

Article

ISSN

16000609
09024441

DOI

10.1111/j.1600-0609.1994.tb01291.x

Other identifier(s)

2-s2.0-0028214719

Rights

Mahidol University

Rights Holder(s)

SCOPUS

Bibliographic Citation

European Journal of Haematology. Vol.52, No.2 (1994), 87-91

Suggested Citation

Sriprapa Chinprasertsuk, Wanchai Wanachiwanawin, Anong Piankijagum Effect of pyrexia in the formation of intraerythrocytic inclusion bodies and vacuoles in haemolytic crisis of haemoglobin H disease. European Journal of Haematology. Vol.52, No.2 (1994), 87-91. doi:10.1111/j.1600-0609.1994.tb01291.x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/9766

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Title

Effect of pyrexia in the formation of intraerythrocytic inclusion bodies and vacuoles in haemolytic crisis of haemoglobin H disease

Author(s)

Sriprapa Chinprasertsuk
 Wanchai Wanachiwanawin
 Anong Piankijagum

Other Contributor(s)

Mahidol University

Abstract

Abstract:  Clinical aspects and in vivo formation of inclusion bodies and vacuoles in red cells of patients with haemoglobin H disease were studied and compared during steady state and after pyrexia of acute infections. During period of pyrexia, there were haemolytic crises with significant drops of the steady‐state haemoglobin levels of 8.6 ± 0.9 g/dl to 5.6 ±1.7 g/dl. The phenomenon was observed with splenic enlargement and significant increase of inclusion body formation. The findings suggested that inclusion body formation in red cells during pyrexia of acute infections played an important role in haemolytic crisis of haemoglobin H disease, probably by causing these cells to be sequestered and destroyed in the spleen. © Munksgaard 1994

Keyword(s)

Medicine

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URI

https://repository.li.mahidol.ac.th/handle/20.500.14594/9766

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Scopus 1991-2000