Publication: Phototoxicity of new psoralen-containing gels and creams versus bath PUVA
Issued Date
2005-10-01
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01252208
01252208
01252208
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2-s2.0-30844455151
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of the Medical Association of Thailand. Vol.88, No.10 (2005), 1406-1411
Suggested Citation
Peerapat Nimkulrat, Vichit Leenutaphong, Srismorn Sudtim Phototoxicity of new psoralen-containing gels and creams versus bath PUVA. Journal of the Medical Association of Thailand. Vol.88, No.10 (2005), 1406-1411. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/16803
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Title
Phototoxicity of new psoralen-containing gels and creams versus bath PUVA
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Abstract
Background: Bath-PUVA-photochemotherapy has become a useful alternative to oral PUVA therapy due to a number of advantages over systemic PUVA, for example, no ophthalmologic risk and nausea, and a lower cumulative UVA doses. However, its major disadvantage is the logistical requirement for bath tubs in practice and some patients feel uncomfortable to share the same bath with others. Topical psoralen contained preparation may be a good candidate for safe, convenient, and useful regimen in the topical PUVA therapy. Objectives: The purpose of the present study was to investigate the intensity of the phototoxic response of 8-MOP bath solution to different concentrations of preparations of 8-MOP gels and creams. Material and Method: Following informed consent, the test bath solution (0.375%), gels (0.0025% to 0.010%) and creams (0.0025% to 0.010%) were applied to the normal-appearing skin of the upper back of 23 volunteers who had no history of photosensitivity. The escalating UVA doses (0.25 to 7.0 J/cm2) were given 15 minutes after application of test substances. Seventy-two hours after UVA exposure minimal phototoxic doses (MPD) were defined visually and the intensity of the erythema response was also assessed by using a narrow-band spectrophotometer. The MPD and the dose-response curves for erythema response of the gels and creams were compared with those of the bath. Results: There were no significant differences between the overall mean MPD of tested gels and that of bath solution (p > 0.05). On the contrary, the cream preparations induced phototoxic response (MPDs) to a lesser degree than bath solution and gels (p < 0.05). When comparing the slope of the dose-response curve for erythema of 0.0025% and 0.0100% gel to that of the bath solution, the correlation is very strong (R 2 = 0.987 and 0.936, respectively, p < 0.0001). Conclusion: The present study shows that the threshold of phototoxic response of 0.0025% 8-MOP gel indicated by MPD is well correlated with those of the bath solution. The slope of the dose-response curve for erythema of this preparation also significantly corresponded to that of the bath solution. Thus, the penetration and drug delivery of 0.0025% 8-methoxypsoralen gel may be similar to 8-methoxypsoralen bath solution. This preparation may be a good candidate for a useful therapeutic modality for topical PUVA therapy, and further clinical trial should be performed.