Publication: Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais
Issued Date
2020-08-04
Resource Type
ISSN
15376613
Other identifier(s)
2-s2.0-85089124689
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Journal of infectious diseases. Vol.222, No.5 (2020), 840-846
Suggested Citation
Panpimon Luangtrakool, Sasijit Vejbaesya, Komon Luangtrakool, Somporn Ngamhawornwong, Kusuma Apisawes, Siripen Kalayanarooj, Louis R. Macareo, Stefan Fernandez, Richard G. Jarman, Robert W.M. Collins, Steven T. Cox, Anon Srikiatkhachorn, Alan L. Rothman, Henry A.F. Stephens Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais. The Journal of infectious diseases. Vol.222, No.5 (2020), 840-846. doi:10.1093/infdis/jiaa134 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/58030
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais
Other Contributor(s)
The Royal Free Hospital
University of Rhode Island Feinstein Providence Campus
King Mongkut's Institute of Technology Ladkrabang
Armed Forces Research Institute of Medical Sciences, Thailand
Walter Reed Army Institute of Research
Faculty of Medicine, Siriraj Hospital, Mahidol University
Queen Sirikit National Institute of Child Health
Guy's Hospital
University of Rhode Island Feinstein Providence Campus
King Mongkut's Institute of Technology Ladkrabang
Armed Forces Research Institute of Medical Sciences, Thailand
Walter Reed Army Institute of Research
Faculty of Medicine, Siriraj Hospital, Mahidol University
Queen Sirikit National Institute of Child Health
Guy's Hospital
Abstract
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. BACKGROUND: Major histocompatibility complex class I chain-related (MIC) A and B (MICA and MICB) are polymorphic stress molecules recognized by natural killer cells. This study was performed to analyze MIC gene profiles in hospitalized Thai children with acute dengue illness. METHODS: MIC allele profiles were determined in a discovery cohort of patients with dengue fever or dengue hemorrhagic fever (DHF) (n = 166) and controls (n = 149). A replication cohort of patients with dengue (n = 222) was used to confirm specific MICB associations with disease. RESULTS: MICA*045 and MICB*004 associated with susceptibility to DHF in secondary dengue virus (DENV) infections (odds ratio [OR], 3.22; [95% confidence interval (CI), 1.18-8.84] and 1.99 [1.07-2.13], respectively), and MICB*002 with protection from DHF in secondary DENV infections (OR, 0.41; 95% CI, .21-.68). The protective effect of MICB*002 against secondary DHF was confirmed in the replication cohort (OR, 0.43; 95% CI, .22-.82) and was stronger when MICB*002 is present in individuals also carrying HLA-B*18, B*40, and B*44 alleles which form the B44 supertype of functionally related alleles (0.29, 95% CI, .14-.60). CONCLUSIONS: Given that MICB*002 is a low expresser of soluble proteins, these data indicate that surface expression of MICB*002 with B44 supertype alleles on DENV-infected cells confer a protective advantage in controlling DENV infection using natural killer cells.