Publication: Follicular induction and CK20+ Merkel cells overlying cutaneous focal mucinosis
Issued Date
2019-03-01
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ISSN
16000560
03036987
03036987
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2-s2.0-85059934797
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Cutaneous Pathology. Vol.46, No.3 (2019), 195-198
Suggested Citation
Manasmon Chairatchaneeboon, Rosalie Elenitsas, Jennifer V. Nguyen Follicular induction and CK20+ Merkel cells overlying cutaneous focal mucinosis. Journal of Cutaneous Pathology. Vol.46, No.3 (2019), 195-198. doi:10.1111/cup.13402 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/51827
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Title
Follicular induction and CK20+ Merkel cells overlying cutaneous focal mucinosis
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Abstract
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. Background: Cutaneous focal mucinosis (CFM) or focal dermal mucinosis is a benign reactive process categorized as a primary mucinosis. Skin biopsy is essential for diagnosis, as the clinical appearance is often non-specific. Follicular induction is a phenomenon whereby the epidermis is induced by an underlying process to form primitive or mature hair follicles, and is commonly seen overlying dermatofibromas. Follicular induction has been rarely described in CFM. Methods: We performed a retrospective histological review of lesions of CFM confirmed by skin biopsy from 2010 to 2015 in our department. Results: We found that 11% (11/98) of CFM lesions showed follicular induction. Cytokeratin 20 (CK20) immunostaining was performed on all 11 of these biopsies that showed follicular induction and highlighted an increased density of CK20+ Merkel cells within the basaloid epidermal proliferations. Conclusion: As superficial basal cell carcinomas (BCC) often show a mucinous stroma around the basaloid islands, CFM with follicular induction may closely mimic a BCC histologically, particularly in superficial shave biopsies. Therefore, it is important that dermatopathologists be aware of this phenomenon. Furthermore, CK20+ staining within the basaloid epithelial proliferations may be helpful in differentiating CFM with follicular induction from a BCC.
