Publication: Modeling dynamics of HIV infected cells using stochastic cellular automaton
Issued Date
2014-08-01
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ISSN
03784371
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2-s2.0-84899547219
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Mahidol University
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SCOPUS
Bibliographic Citation
Physica A: Statistical Mechanics and its Applications. Vol.407, (2014), 303-311
Suggested Citation
Monamorn Precharattana, Wannapong Triampo Modeling dynamics of HIV infected cells using stochastic cellular automaton. Physica A: Statistical Mechanics and its Applications. Vol.407, (2014), 303-311. doi:10.1016/j.physa.2014.04.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/34126
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Title
Modeling dynamics of HIV infected cells using stochastic cellular automaton
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Abstract
Ever since HIV was first diagnosed in human, a great number of scientific works have been undertaken to explore the biological mechanisms involved in the infection and progression of the disease. Several cellular automata (CA) models have been introduced to gain insights into the dynamics of the disease progression but none of them has taken into account effects of certain immune cells such as the dendritic cells (DCs) and the CD8+T lymphocytes (CD8+T cells). In this work, we present a CA model, which incorporates effects of the HIV specific immune response focusing on the cell-mediated immunities, and investigate the interaction between the host immune response and the HIV infected cells in the lymph nodes. The aim of our work is to propose a model more realistic than the one in Precharattana et al. (2010) [10], by incorporating roles of the DCs, the CD4+T cells, and the CD8+T cells into the model so that it would reproduce the HIV infection dynamics during the primary phase of HIV infection. © 2014 Elsevier B.V. All rights reserved.