Publication: Relationship between aging and susceptibility of erythrocytes to oxidative damage: In view of nutraceutical interventions
Issued Date
2006-06-01
Resource Type
ISSN
15491684
Other identifier(s)
2-s2.0-33744952661
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Rejuvenation Research. Vol.9, No.2 (2006), 227-230
Suggested Citation
F. Marotta, K. Pavasuthipaisit, C. Yoshida, F. Albergati, P. Marandola Relationship between aging and susceptibility of erythrocytes to oxidative damage: In view of nutraceutical interventions. Rejuvenation Research. Vol.9, No.2 (2006), 227-230. doi:10.1089/rej.2006.9.227 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/23030
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Title
Relationship between aging and susceptibility of erythrocytes to oxidative damage: In view of nutraceutical interventions
Abstract
Twelve (12) healthy elderly subjects were divided into two groups: (a) those given an antioxidant/NO-modulating fermented papaya preparation (FPP) 9 g/day for 4 weeks, and (b) a placebo group. No protein/lipid distribution in erythrocytes (RBC) membranes was noted among different ages and treatments. Higher RBC concentration of malondialdehyde and nitric oxide synthase were found in the elderly (p < 0.05 versus "young" controls), whereas superoxide dismutase was unaltered. Such abnormalities were prevented by FPP supplementation (p < 0.01). RBC and RBC ghosts showed an enhanced susceptibility to lipid peroxidation by using cumene hydroperoxide (p < 0.01 versus young) but FPP supplementation significantly protected intact RBC (p < 0.05). These preliminary data suggest that nutraceuticals with antioxidant/NO-regulating properties significantly protect from RBC oxidative damage, and are potential weapons for the aging process and chronic and degenerative diseases. © Mary Ann Liebert, Inc.