Publication: Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype
Issued Date
1996-11-01
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ISSN
0022538X
Other identifier(s)
2-s2.0-10244249213
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Virology. Vol.70, No.11 (1996), 7827-7832
Suggested Citation
Jonathan Weber, Eva Maria Fenyö, Simon Beddows, Pontiano Kaleebu, Åsa Björndal, S. Osmanov, W. Heyward, J. Esparza, B. Galvao-Castro, P. Van De Perre, E. Karita, C. Wasi, S. Sempala, B. Tugume, B. Biryahwaho, H. Rübsamen-Waigmann, H. Von Briesen, R. Esser, M. Grez, H. Holmes, A. Newberry, S. Ranjhar, P. Tomlinson, J. Bradac Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype. Journal of Virology. Vol.70, No.11 (1996), 7827-7832. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17515
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Title
Neutralization serotypes of human immunodeficiency virus type 1 field isolates are not predicted by genetic subtype
Author(s)
Jonathan Weber
Eva Maria Fenyö
Simon Beddows
Pontiano Kaleebu
Åsa Björndal
S. Osmanov
W. Heyward
J. Esparza
B. Galvao-Castro
P. Van De Perre
E. Karita
C. Wasi
S. Sempala
B. Tugume
B. Biryahwaho
H. Rübsamen-Waigmann
H. Von Briesen
R. Esser
M. Grez
H. Holmes
A. Newberry
S. Ranjhar
P. Tomlinson
J. Bradac
Eva Maria Fenyö
Simon Beddows
Pontiano Kaleebu
Åsa Björndal
S. Osmanov
W. Heyward
J. Esparza
B. Galvao-Castro
P. Van De Perre
E. Karita
C. Wasi
S. Sempala
B. Tugume
B. Biryahwaho
H. Rübsamen-Waigmann
H. Von Briesen
R. Esser
M. Grez
H. Holmes
A. Newberry
S. Ranjhar
P. Tomlinson
J. Bradac
Other Contributor(s)
Abstract
Human immunodeficiency virus type 1 (HIV-1) primary isolates from four geographical locations in Thailand, Brazil, Rwanda, and Uganda, representing genetic subtypes A, B, C, D, and E, were examined for autologous and heterologous neutralization by panels of human HIV+polyclonal plasma. In independent linked experiments in three laboratories using diverse methodologies and common reagents, no defined pattern of genetic subtype- specific neutralization was observed. Most plasma tested were broadly cross- neutralizing across two or more genetic subtypes, although the titer of neutralization varied across a wide range. We conclude that the genetic subtypes of HIV-1 are not classical neutralization serotypes.