Publication: Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis
Issued Date
2016-07-01
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ISSN
16000781
09054383
09054383
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2-s2.0-84963823283
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Mahidol University
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SCOPUS
Bibliographic Citation
Photodermatology Photoimmunology and Photomedicine. Vol.32, No.4 (2016), 181-190
Suggested Citation
Sikarin Upala, Anawin Sanguankeo Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis. Photodermatology Photoimmunology and Photomedicine. Vol.32, No.4 (2016), 181-190. doi:10.1111/phpp.12241 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/40786
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Title
Low 25-hydroxyvitamin D levels are associated with vitiligo: a systematic review and meta-analysis
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Abstract
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Background: Vitamin D deficiency is associated with a number of autoimmune diseases. We completed a meta-analysis of observational studies to establish whether there was a relationship between hypovitaminosis D and the autoimmune skin disease vitiligo. Methods: Comprehensive search was applied in the MEDLINE and EMBASE databases from their inception to December 2015. Inclusion criteria were observational studies that assessed 25-hydroxyvitamin D (25(OH)D) levels in adults with vitiligo. The main outcome was the mean difference in serum 25(OH)D level between patients with vitiligo and controls. Results: Our search strategy identified 383 articles; seventeen studies met the criteria for full-length review and seven studies, containing the data of 1200 patients, were included in a random-effects model meta-analysis. The pooled mean difference in serum 25-hydroxyvitamin D concentration between patients with vitiligo and controls was −7.45 ng/ml (95% confidence interval, −12.99 to −1.91, P-value = 0.01). The between-study heterogeneity (I2) was 96%, P = value<0.001. Conclusions: This meta-analysis identifies a significant relationship between low 25-hydroxyvitamin D levels and vitiligo, but does not prove causation. Our findings emphasize the importance of measuring 25-hydroxyvitamin D levels in patients with vitiligo. Further studies will be needed to establish whether vitamin D supplementation in this population improves the outcome of vitiligo.