Publication: Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in The Netherlands
Issued Date
2000-01-01
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ISSN
00221899
DOI
Other identifier(s)
2-s2.0-0033711560
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.182, No.6 (2000), 1788-1790
Suggested Citation
David A. Schwartz, Suthi Sungkarat, Nathan Shaffer, Jirasak Laosakkitiboran, Wendy Supapol, Pichai Charoenpanich, Tuenjai Chuangsuwanich, Timothy D. Mastro Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in The Netherlands. Journal of Infectious Diseases. Vol.182, No.6 (2000), 1788-1790. doi:10.1086/317598 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26346
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Title
Mutations at amino acid position 315 of the katG gene are associated with high-level resistance to isoniazid, other drug resistance, and successful transmission of Mycobacterium tuberculosis in The Netherlands
Abstract
The effects of human immunodeficiency virus (HIV) type 1 on the placenta and the role of the placenta in mother-to-child HIV-1 transmission are not well understood. Placentas from 78 HIV-infected and 158 HIV-uninfected women were examined as part of a prospective perinatal HIV transmission study in Bangkok. HIV-infected women were more likely than HIV-uninfected women to have chorioamnionitis (odds ratio [OR], 2.1; P = .03), placental membrane inflammation (PMI; OR, 2.7; P = .02), and deciduitis (OR, 2.3; P = .03) and less likely to have villitis (OR, 0.3; P = .02). However, among HIV-infected women, fewer women who transmitted infection to their child had chorioamnionitis (relative risk [RR], 0.2; P = .03), funisitis (RR, 0.4; P =. 1), or PMI (RR undefined; P = .03). These findings suggest that, in this population, HIV-infected women are at increased risk for placental membrane inflammatory lesions, but that placental inflammatory lesions are not associated with increased perinatal HIV transmission. © Oxford University Press 2001.