Publication: HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Filipino patients
Issued Date
2021-06-01
Resource Type
ISSN
17448042
14622416
14622416
Other identifier(s)
2-s2.0-85107464545
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Mahidol University
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SCOPUS
Bibliographic Citation
Pharmacogenomics. Vol.22, No.8 (2021), 465-472
Suggested Citation
Francis Capule, Pramote Tragulpiankit, Surakameth Mahasirimongkol, Jiraphun Jittikoon, Nuanjun Wichukchinda, Lara Theresa Alentajan-Aleta, Jay V.James Barit, Josephine Casanova-Gutierrez, Leonor Cabral-Lim, Jose Paciano Baltazar Reyes, Francisca Roa, Raymark Salonga, Katrina Faith San Gabriel, Catherine Lynn Silao HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Filipino patients. Pharmacogenomics. Vol.22, No.8 (2021), 465-472. doi:10.2217/pgs-2020-0191 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/76158
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Title
HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Filipino patients
Author(s)
Francis Capule
Pramote Tragulpiankit
Surakameth Mahasirimongkol
Jiraphun Jittikoon
Nuanjun Wichukchinda
Lara Theresa Alentajan-Aleta
Jay V.James Barit
Josephine Casanova-Gutierrez
Leonor Cabral-Lim
Jose Paciano Baltazar Reyes
Francisca Roa
Raymark Salonga
Katrina Faith San Gabriel
Catherine Lynn Silao
Pramote Tragulpiankit
Surakameth Mahasirimongkol
Jiraphun Jittikoon
Nuanjun Wichukchinda
Lara Theresa Alentajan-Aleta
Jay V.James Barit
Josephine Casanova-Gutierrez
Leonor Cabral-Lim
Jose Paciano Baltazar Reyes
Francisca Roa
Raymark Salonga
Katrina Faith San Gabriel
Catherine Lynn Silao
Abstract
Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5-76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1-20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2-30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.