Publication: Promoting effect of 2,4-diaminoanisole sulfate on rat thyroid carcinogenesis
Issued Date
1989-01-01
Resource Type
ISSN
03043835
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2-s2.0-0024401067
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Mahidol University
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SCOPUS
Bibliographic Citation
Cancer Letters. Vol.45, No.2 (1989), 115-121
Suggested Citation
Y. Kitahori, M. Ohshima, H. Matsuki, N. Konishi, H. Hashimoto, S. Minami, W. Thamavit, Y. Hiasa Promoting effect of 2,4-diaminoanisole sulfate on rat thyroid carcinogenesis. Cancer Letters. Vol.45, No.2 (1989), 115-121. doi:10.1016/0304-3835(89)90145-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/15725
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Title
Promoting effect of 2,4-diaminoanisole sulfate on rat thyroid carcinogenesis
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Abstract
Two experiments were conducted to examine the effects of 2,4-diaminoanisole sulfate (2,4-DAAS) on thyroid function and carcinogenesis in male Wistar rats. In experiment 1, feeding with 2,4-DAAS resulted in significantly elevated levels of thyroid stimulating hormone (TSH), reduced thyroxine (T 4 ) and triiodothyronine (T 3 ) in the serum, although the latter had almost recovered to normal levels by week 6. However, skin application did not affect serum levels. In experiment 2, administration of 0.5% 2,4-DAAS in the diet for 19 weeks, a week after a single 210 mg 100 g body weight i.p. injection of N-bis(2-hydroxypropyl)nitrosamine (DHPN), significantly increased the incidence and numbers of preneoplastic lesions (focal hyperplasia), adenomas and carcinomas developing in the thyroid gland. Histologically, brown pigment was usually observed within follicular epithelial cells in non-tumorous regions, but not in the tumors themselves. © 1989.