Publication: Estimated rate of HIV-1-infectious but seronegative blood donations in Bangkok, Thailand
Issued Date
1996-09-09
Resource Type
ISSN
02699370
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2-s2.0-0029814738
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Mahidol University
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SCOPUS
Bibliographic Citation
AIDS. Vol.10, No.10 (1996), 1157-1162
Suggested Citation
Dwip Kitayaporn, Jaranit Kaewkungwal, Sasitorn Bejrachandra, Ekaraj Rungroung, Dasnayanee Chandanayingyong, Timothy D. Mastro Estimated rate of HIV-1-infectious but seronegative blood donations in Bangkok, Thailand. AIDS. Vol.10, No.10 (1996), 1157-1162. Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/17614
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Title
Estimated rate of HIV-1-infectious but seronegative blood donations in Bangkok, Thailand
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Abstract
Objectives: To determine HIV seroprevalence and incidence among various blood donor types, and to estimate the rate of window-period blood donations. Design: Retrospective cohort from computerized donor records. Methods: Records were analysed from all 60 483 donors (contributing 97 464 donor units) at a public university teaching hospital blood bank in Bangkok, Thailand, from 1 January 1990 to 30 June 1993. Annual HIV incidence among 14 482 repeat donors who were HIV-seronegative on their first donation was calculated assuming equal probability of seroconversion between last seronegative and first seropositive donations. To estimate the probability of window-period donations, we assumed that the time from HIV infectivity to onset of detectable antibody was 45 days. Results: In 1990, HIV incidence calculated for all repeat donors was 307 per 100 000 person-years; the probability of a window-period donation was 38 in 100 000 donations or one in 2644 donations. During 1991-1993, this probability decreased by one-half. However, one-time donors were more than twice as likely as repeat donors to be HIV-1-seropositive. Conclusions: The rate of HIV window-period blood donations among Thai repeat donors was relatively high compared with that in developed countries and was probably even higher among one-time donors. Improved donor deferral criteria are needed in Thailand.