Publication: Preliminary evaluation of the analgesic and anti-inflammatory effects of Tacca integrifolia in rodents
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Issued Date
2015
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eng
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Mahidol University
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IJARNP-HS Publication
Bibliographic Citation
International Journal of Applied Research in Natural Products. vol.8, no.1 (2015), 20-25
Suggested Citation
Thatree Autsavakitipong, Parirat Khonsung, Ampai Panthong, Natthakarn Chiranthanut, Puongtip Kunanusorn, Narong Nuntasaen, Thaworn Jaipetch, Samreang Bunteang, Vichai Reutrakul Preliminary evaluation of the analgesic and anti-inflammatory effects of Tacca integrifolia in rodents. International Journal of Applied Research in Natural Products. vol.8, no.1 (2015), 20-25. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/1375
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Title
Preliminary evaluation of the analgesic and anti-inflammatory effects of Tacca integrifolia in rodents
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Abstract
Summary. This is a preliminary investigation of the ethyl acetate extract of the leaf of Tacca integrifolia (TIE) for the analgesic activity
using writhing response in mice, tail flick test in rats and for anti-inflammatory activity using ethyl phenyl propiolate (EPP)-induced ear
edema, carrageenan- and arachidonic acid-induced hind paw edema, as well as cotton pellet-induced granuloma formation in rats. The
results showed that TIE (200 mg/kg, PO) significantly inhibited pain caused by acetic acid injection (65.9%) but did not exhibit effect in tail
flick test in rats. These findings suggest that analgesic mechanism of TIE may act via peripherally pathway. The study of anti-inflammatory
effect showed that TIE significantly inhibited ear edema induced by EPP. TIE (200 mg/kg, PO) inhibited paw edema induced by
carrageenan (55.5%) and arachidonic acid (48.6%) but had no effect on cotton-induced granuloma formation in rats. In conclusion, the ethyl
acetate extract of leaf of T. integrifolia possessed anti-inflammatory activity in acute inflammation and analgesic activity.
Industrial relevant. Plants of the genus Tacca have been reported to possess many activities such as analgesic, anti-inflammatory and,
antipyretic activities. Many species have been used to treat high blood pressure, burn, gastric ulcer, and hepatitis. The scientific studies
supporting the traditional uses of Tacca integrifolia for some of the alleged activities are still lacking. The screening test for analgesic and
anti-inflammatory effect of the ethyl acetate extract of the leaf of Tacca integrifolia provides scientific data to confirm the potentials of T.
integrifolia as an analgesic and anti-inflammatory
anti-inflammatory drug in the future.