Publication: Alterations of organ histopathology and metallolhionein mRNA expression in silver barb, Puntius gonionotus during subchronic cadmium exposure
Issued Date
2007-11-21
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10010742
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2-s2.0-36148964077
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Mahidol University
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SCOPUS
Bibliographic Citation
Journal of Environmental Sciences. Vol.19, No.11 (2007), 1341-1348
Suggested Citation
Alisa Wangsongsak, Suwimol Utarnpongsa, Maleeya Kruatrachue, Mathurose Ponglikitmongkol, Prayad Pokethitiyook, Thitinun Sumranwanich Alterations of organ histopathology and metallolhionein mRNA expression in silver barb, Puntius gonionotus during subchronic cadmium exposure. Journal of Environmental Sciences. Vol.19, No.11 (2007), 1341-1348. doi:10.1016/S1001-0742(07)60219-8 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/24456
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Title
Alterations of organ histopathology and metallolhionein mRNA expression in silver barb, Puntius gonionotus during subchronic cadmium exposure
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Abstract
Common silver barb, Puntius gonionotus, exposed to the nominal concentration of 0.06 mg/L Cd for 60 d, were assessed for histopathological alterations (gills, liver and kidney), metal accumulation, and metallothionein (MT) mRNA expression. Fish exhibited pathological symptoms such as hypertrophy and hyperplasia of primary and secondary gill lamellae, vacuolization in hepatocytes, and prominent tubular and glomerular damage in the kidney. In addition, kidney accumulated the highest content of cadmium, more than gills and liver. Expression of MT mRNA was increased in both liver and kidney of treated fish. Hepatic MT levels remained high after fish were removed to Cd-free water. In contrast, MT expression in kidney was peaked after 28 d of treatment and drastically dropped when fish were removed to Cd-free water. The high concentrations of Cd in hepatic tissues indicated an accumulation site or permanent damage on this tissue. © 2007 The Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences.