Publication: Antibodies specific for heat shock proteins in human and murine malaria
Issued Date
2001-04-01
Resource Type
ISSN
12864579
Other identifier(s)
2-s2.0-0035026620
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Mahidol University
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SCOPUS
Bibliographic Citation
Microbes and Infection. Vol.3, No.5 (2001), 363-367
Suggested Citation
Manxin Zhang, Hajime Hisaeda, Shigeyuki Kano, Yoshitsugu Matsumoto, Yan Peng Hao, Sornchai Looaresuwan, Masamichi Aikawa, Kunisuke Himeno Antibodies specific for heat shock proteins in human and murine malaria. Microbes and Infection. Vol.3, No.5 (2001), 363-367. doi:10.1016/S1286-4579(01)01391-0 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/26570
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Title
Antibodies specific for heat shock proteins in human and murine malaria
Abstract
Heat shock proteins (HSPs) are immunodominant antigens recognized by the host immune system in various infectious diseases. We analyzed HSP-specific antibodies, including immunoglobulin G (IgG), IgM and IgA, in sera from malaria patients in Thailand by using an enzyme-linked immunosorbent assay. All of the antibodies to HSP90 were remarkably increased in the patients compared with those in controls, while only IgM to HSP70 or IgA to HSP65 was significantly elevated. Further experiments showed that anti-HSP IgG was significantly increased in C57BL/6 mice infected with a non-lethal strain of Plasmodium yoelii, with anti-HSP90 IgG being the most elevated. These results suggest that the antigenic potential of HSP90 is higher than those of HSP70 and HSP65 in malaria infection. © 2001 Éditions scientifiques et médicales Elsevier SAS.