Publication: Mefloquine prophylaxis prevents malaria during pregnancy: A double-blind, placebo-controlled study
3
Issued Date
1994-01-01
Resource Type
ISSN
15376613
00221899
00221899
Other identifier(s)
2-s2.0-0028009814
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Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Infectious Diseases. Vol.169, No.3 (1994), 595-603
Suggested Citation
F. Nosten, F. Ter Kuile, L. Maelankiri, T. Chongsuphajaisiddhi, L. Nopdonrattakoon, S. Tangkitchot, E. Boudreau, D. Bunnag, N. J. White Mefloquine prophylaxis prevents malaria during pregnancy: A double-blind, placebo-controlled study. Journal of Infectious Diseases. Vol.169, No.3 (1994), 595-603. doi:10.1093/infdis/169.3.595 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/9846
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Title
Mefloquine prophylaxis prevents malaria during pregnancy: A double-blind, placebo-controlled study
Abstract
A double-blind, placebo-controlled study of mefloquine antimalarial prophylaxis in pregnancy ( > 20 weeks of gestation) was conducted in 339 Karen women living in an area of multidrug-resistant malaria transmission on the Thai-Burmese border. Mefloquine gave ≥86% (95% confidence interval [CI], 59%-94%) protection against Plasmodium falciparum and complete protection against Plasmodium vivax infections. Mefloquine prophylaxis was welltolerated; use of an initial loading dose (10 mg/kg) was associated with transient dizziness, but there were no other significant adverse effectson the mother, the pregnancy, or infant survivalor development(followed for 2 years). Falciparum malaria was associated with maternal anemia and a mean reduction in birth weight in gravidae I, II, and III of225 g (95%CI, 26-423). Maternal anemia at delivery(hematocrit < 30%) was associated with increased infant mortality: 26% versus 15% (relative risk, 1.9; 95% CI, 1.1-3.2). Mefloquine is safe and effective for antimalarial prophylaxis in the second half of pregnancy. © 1994 by The University of Chicago.