Publication: Local treatment with a polycarbophil-based cream in postmenopausal women with genitourinary syndrome of menopause
Issued Date
2020-01-01
Resource Type
ISSN
14333023
09373462
09373462
Other identifier(s)
2-s2.0-85083401044
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Urogynecology Journal. (2020)
Suggested Citation
Tipatai Yodplob, Kun Sirisopana, Mutita Jongwannasiri, Pokket Sirisreetreerux, Wit Viseshsindh, Wachira Kochakarn Local treatment with a polycarbophil-based cream in postmenopausal women with genitourinary syndrome of menopause. International Urogynecology Journal. (2020). doi:10.1007/s00192-020-04282-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/54642
Research Projects
Organizational Units
Authors
Journal Issue
Thesis
Title
Local treatment with a polycarbophil-based cream in postmenopausal women with genitourinary syndrome of menopause
Other Contributor(s)
Abstract
© 2020, The Author(s). Introduction and hypothesis: Genitourinary syndrome of menopause (GSM) is a common problem associated with lower urinary tract and gynecological symptoms due to the decrease in estrogen production in postmenopausal women. Topical estrogen therapy is shown to improve these symptoms; nonetheless, there are limited data on the efficacy of nonhormonal moisturizers in these patients. Methods: A prospective cohort study was conducted to compare the symptoms of GSM before and after treatment with a polycarbophil-based cream in 42 women. The quality of life (QoL) and sexual scores were obtained from the Thai version of the International Consultation on Incontinence Modular Questionnaire-Lower Urinary Tract Symptoms (ICIQ-LUTS) along with uroflow measurements before and 4 and 12 weeks after treatment. Results: Significant improvements in ICIQ-LUTSqol scores were observed after 4 weeks (9.38 ± 7.47 vs 6.76 ± 5.77; p = 0.017) and 12 weeks (10.03 ± 7.49 vs 5.97 ± 4.02; p = 0.002) when compared with the baseline values before treatment. The ICIQ-LUTS sexual scores were also improved after treatment at 4 weeks (2.29 ± 2.26 vs 0.88 ± 1.34; p < 0.001) and 12 weeks (2.13 ± 2.22 vs 0.42 ± 0.81; p < 0.001) compared with the baseline scores. No differences in ICIQ-LUTSqol and sexual scores were observed between the 4- and 12-week treatment groups. Conclusion: The polycarbophil-based cream improved the overall LUTS and sexual symptoms in the patients with GSM, thus indicating that the nonhormonal polycarbophil-based cream may prove effective for the treatment for women with this condition.