Publication: Secretory autophagy
Issued Date
2015-08-01
Resource Type
ISSN
18790410
09550674
09550674
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2-s2.0-84938693671
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Mahidol University
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SCOPUS
Bibliographic Citation
Current Opinion in Cell Biology. Vol.35, (2015), 106-116
Suggested Citation
Marisa Ponpuak, Michael A. Mandell, Tomonori Kimura, Santosh Chauhan, Cédric Cleyrat, Vojo Deretic Secretory autophagy. Current Opinion in Cell Biology. Vol.35, (2015), 106-116. doi:10.1016/j.ceb.2015.04.016 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/35407
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Title
Secretory autophagy
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Abstract
© 2015 Elsevier Ltd. Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less intuitive but biologically distinct non-degradative roles. One manifestation of these functions of the autophagic machinery is the process termed secretory autophagy. Secretory autophagy facilitates unconventional secretion of the cytosolic cargo such as leaderless cytosolic proteins, which unlike proteins endowed with the leader (N-terminal signal) peptides cannot enter the conventional secretory pathway normally operating via the endoplasmic reticulum and the Golgi apparatus. Secretory autophagy may also export more complex cytoplasmic cargo and help excrete particulate substrates. Autophagic machinery and autophagy as a process also affect conventional secretory pathways, including the constitutive and regulated secretion, as well as promote alternative routes for trafficking of integral membrane proteins to the plasma membrane. Thus, autophagy and autophagic factors are intimately intertwined at many levels with secretion and polarized sorting in eukaryotic cells.