Publication:
Association of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal women

dc.contributor.authorRatchakrit Srikueaen_US
dc.contributor.authorT. Brock Symonsen_US
dc.contributor.authorDouglas E. Longen_US
dc.contributor.authorJonah D. Leeen_US
dc.contributor.authorYu Shangen_US
dc.contributor.authorPeter J. Chomentowskien_US
dc.contributor.authorGuoqiang Yuen_US
dc.contributor.authorLeslie J. Crofforden_US
dc.contributor.authorCharlotte A. Petersonen_US
dc.contributor.otherUniversity of Kentuckyen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherEastern Kentucky Universityen_US
dc.date.accessioned2018-10-19T05:05:45Z
dc.date.available2018-10-19T05:05:45Z
dc.date.issued2013-02-01en_US
dc.description.abstractObjective To identify muscle physiologic properties that may contribute to postexertional fatigue and malaise in women with fibromyalgia (FM). Methods Healthy postmenopausal women with (n = 11) and without (n = 11) FM, ages 51-70 years, participated in this study. Physical characteristics and responses to self-reported questionnaires were evaluated. Strength loss and tissue oxygenation in response to a fatiguing exercise protocol were used to quantify fatigability and the local muscle hemodynamic profile. Muscle biopsies were performed to assess between-group differences in baseline muscle properties using histochemical, immunohistochemical, and electron microscopic analyses. Results There was no significant difference between healthy controls and FM patients in muscle fatigue in response to exercise. However, self-reported fatigue and pain were correlated with prolonged loss of strength following 12 minutes of recovery in patients with FM. Although there was no difference in percent succinate dehydrogenase (SDH)-positive (type I) and SDH-negative (type II) fibers or in mean fiber cross-sectional area between groups, FM patients exhibited greater variability in fiber size and altered fiber size distribution. In healthy controls only, fatigue resistance was strongly correlated with the size of SDH-positive fibers and hemoglobin oxygenation. In contrast, FM patients with the highest percentage of SDH-positive fibers recovered strength most effectively, and this was correlated with capillary density. However, overall, capillary density was lower in the FM group. Conclusion Peripheral mechanisms, i.e., altered muscle fiber size distribution and decreased capillary density, may contribute to postexertional fatigue in FM. Understanding of these defects in fibromyalgic muscle may provide valuable insight with regard to treatment. Copyright © 2013 by the American College of Rheumatology.en_US
dc.identifier.citationArthritis and Rheumatism. Vol.65, No.2 (2013), 519-528en_US
dc.identifier.doi10.1002/art.37763en_US
dc.identifier.issn15290131en_US
dc.identifier.issn00043591en_US
dc.identifier.other2-s2.0-84873832408en_US
dc.identifier.urihttps://repository.li.mahidol.ac.th/handle/20.500.14594/31969
dc.rightsMahidol Universityen_US
dc.rights.holderSCOPUSen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873832408&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.subjectMedicineen_US
dc.titleAssociation of fibromyalgia with altered skeletal muscle characteristics which may contribute to postexertional fatigue in postmenopausal womenen_US
dc.typeArticleen_US
dspace.entity.typePublication
mu.datasource.scopushttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873832408&origin=inwarden_US

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