Publication: Treating iron overload in patients with non-transfusion-dependent thalassemia
Issued Date
2013-05-01
Resource Type
ISSN
10968652
03618609
03618609
Other identifier(s)
2-s2.0-84876713390
Rights
Mahidol University
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Hematology. Vol.88, No.5 (2013), 409-415
Suggested Citation
Ali T. Taher, Vip Viprakasit, Khaled M. Musallam, M. Domenica Cappellini Treating iron overload in patients with non-transfusion-dependent thalassemia. American Journal of Hematology. Vol.88, No.5 (2013), 409-415. doi:10.1002/ajh.23405 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/32373
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Title
Treating iron overload in patients with non-transfusion-dependent thalassemia
Abstract
Despite receiving no or only occasional blood transfusions, patients with non-transfusion-dependent thalassemia (NTDT) have increased intestinal iron absorption and can accumulate iron to levels comparable with transfusion-dependent patients. This iron accumulation occurs more slowly in NTDT patients compared to transfusion-dependent thalassemia patients, and complications do not arise until later in life. It remains crucial for these patients' health to monitor and appropriately treat their iron burden. Based on recent data, including a randomized clinical trial on iron chelation in NTDT, a simple iron chelation treatment algorithm is presented to assist physicians with monitoring iron burden and initiating chelation therapy in this group of patients. © 2013 Wiley Periodicals, Inc.