Publication: Economic evaluation of adjuvant trastuzumab therapy for HER2-positive early-stage breast cancer: systematic review and quality assessment
Issued Date
2020-01-01
Resource Type
ISSN
17448379
14737167
14737167
Other identifier(s)
2-s2.0-85091482525
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Mahidol University
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SCOPUS
Bibliographic Citation
Expert Review of Pharmacoeconomics and Outcomes Research. (2020)
Suggested Citation
Anne Julienne Genuino, Mac Ardy Junio Gloria, Usa Chaikledkaew, Thanyanan Reungwetwattana, Ammarin Thakkinstian Economic evaluation of adjuvant trastuzumab therapy for HER2-positive early-stage breast cancer: systematic review and quality assessment. Expert Review of Pharmacoeconomics and Outcomes Research. (2020). doi:10.1080/14737167.2020.1819795 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/59278
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Title
Economic evaluation of adjuvant trastuzumab therapy for HER2-positive early-stage breast cancer: systematic review and quality assessment
Abstract
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Introduction: As the availability of new economic evaluations (EE) on adjuvant trastuzumab therapy for early-stage breast cancer (EBC) with HER2-positive since last search and other EEs missed warrant a more extensive review, this study aimed to systematically review EEs of adjuvant trastuzumab compared with chemotherapy alone for HER2-positive EBC. Area covered: The search was performed in February 2019 using MEDLINE and Scopus. Reviewers independently selected studies based on eligibility criteria, extracted data, assessed quality of reporting, and appraised quality of data sources. Expert opinion: 22 studies were included which were from high-income (HICs) and upper-middle income countries (UMICs). Incremental cost-effectiveness ratios (ICERs) from HICs were within their cost-effectiveness thresholds and ranged from 6,018 to 78,929 USD per quality-adjusted life year (QALY) gained. ICERs from UMICs mostly exceeded their thresholds ranging from 3,526 to 174,901 USD per QALY gained. Evidence shows cost-effectiveness of trastuzumab for HER2-positive EBC in HICs. There were no methodological variations. The extent and adequacy of reporting were high. The quality of data sources was moderate to high. The quality of future EEs can be improved by enhancing the reporting quality, by using context-based data and real-world efficacy data, which would impact cost-effectiveness.