Publication: Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36
Issued Date
2009-02-01
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ISSN
00319422
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2-s2.0-62649168292
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Mahidol University
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SCOPUS
Bibliographic Citation
Phytochemistry. Vol.70, No.3 (2009), 407-413
Suggested Citation
Porntep Chomcheon, Suthep Wiyakrutta, Nongluksna Sriubolmas, Nattaya Ngamrojanavanich, Surapong Kengtong, Chulabhorn Mahidol, Somsak Ruchirawat, Prasat Kittakoop Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36. Phytochemistry. Vol.70, No.3 (2009), 407-413. doi:10.1016/j.phytochem.2009.01.007 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/27061
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Title
Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36
Abstract
Isolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1-8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC50value of 5.30 μM. © 2009 Elsevier Ltd. All rights reserved.