Publication: Antioxidant effects of aqueous extracts from dried calyx of hibiscus sabdariffa LINN. (Roselle) in vitro using rat low-density lipoprotein (LDL)
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Submitted Date
2004-10-15
Issued Date
2005
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
366 kb
ISSN
0918-6158
Rights
Mahidol University
Rights Holder(s)
Pharmaceutical Society of Japan
Bibliographic Citation
Biological and Pharmaceutical Bulletin. Vol.28, No.3 (2005), 481-4
Suggested Citation
Vilasinee Hirunpanich, Anocha Utaipat, Noppawan Phumala Morales, Nantavan Bunyapraphatsara, Sato, Hitoshi, Angkana Herunsalee, Chuthamanee Suthisisang, วิลาสินี หิรัญพานิช, อโนชา อุทัยพัฒน์, นันทวัน บุณยะประภัศร, จุฑามณี สุทธิสีสังข์ Antioxidant effects of aqueous extracts from dried calyx of hibiscus sabdariffa LINN. (Roselle) in vitro using rat low-density lipoprotein (LDL). Biological and Pharmaceutical Bulletin. Vol.28, No.3 (2005), 481-4. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/3062
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Title
Antioxidant effects of aqueous extracts from dried calyx of hibiscus sabdariffa LINN. (Roselle) in vitro using rat low-density lipoprotein (LDL)
Abstract
The present study quantitatively investigated the antioxidant effects of the aqueous extracts from dried calyx of Hibiscus sabdariffa LINN. (roselle) in vitro using rat low-density lipoprotein (LDL). Formations of the conjugated
dienes and thiobarbituric acid reactive substances (TBARs) were monitored as markers of the early and later stages of the oxidation of LDL, respectively. Thus, we demonstrated that the dried calyx extracts of roselle exhibits strong antioxidant activity in Cu2+ -mediated oxidation of LDL (p<0.05) in vitro. The inhibitory effect of
the extracts on LDL oxidation was dose-dependent at concentrations ranging from 0.1 to 5 mg/ml. Moreover, 5 mg/ml of roselle inhibited TBARs-formation with greater potency than 100 mrgM of vitamin E. In conclusion, this study provides a quantitative insight into the potent antioxidant effect of roselle in vitro.