Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial
Issued Date
2024-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85204009321
Journal Title
Scientific Reports
Volume
14
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.14 No.1 (2024)
Suggested Citation
Krittayaphong R., Treesuwan W., Pramyothin P., Songsangjinda T., Kaolawanich Y., Srivanichakorn W., Jangtawee P., Yindeengam A., Tanapibunpon P., Vanavichit A. Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial. Scientific Reports Vol.14 No.1 (2024). doi:10.1038/s41598-024-72246-w Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101301
Title
Impact of diet intervention on visceral adipose tissue and hepatic fat in patients with obesity or type 2 diabetes: a randomized trial
Corresponding Author(s)
Other Contributor(s)
Abstract
This study aimed to assess the effects of a diet intervention on visceral and hepatic fat in patients with obesity or type 2 diabetes (T2D). Participants with obesity or T2D were randomized to a diet intervention or their usual diet. The intervention comprised a “3G rice” regimen combined with a low-salt, high-fiber diet. The primary outcomes were changes in visceral adipose tissue (VAT) area and hepatic fat over 12 weeks assessed by magnetic resonance imaging. Eighty-six patients were randomized. Their mean age was 47.5 ± 11.0 years, and 82.3% were female. Eighty-one (94.2%) had obesity, and 16 (18.6%) had T2D. Baseline metrics were body weight 76.3 ± 16.1 kg, BMI 29.6 ± 4.6, VAT 12 629 ± 5819 mm2, and hepatic fat 7.9% ± 7.2%. At the 12-week follow-up, the diet group had greater VAT and hepatic fat reductions than controls (− 1468 ± 1468 vs. − 179 ± 1576 mm2, P = 0.001; and − 2.6% ± 3.4% vs. 0.4% ± 2.2%, P < 0.001). Adjusted differences remained significant for VAT (− 1093 mm2, P < 0.001) and hepatic fat (− 2.5%, P < 0.001). In conclusion, the 12-week diet intervention decreased VAT, hepatic fat, body weight, and BMI compared to a usual diet.