Evidence of malarial chemoprophylaxis among travellers who died from malaria: a systematic review and meta-analysis
Issued Date
2023-12-01
Resource Type
eISSN
14752875
Scopus ID
2-s2.0-85177659804
Journal Title
Malaria Journal
Volume
22
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Malaria Journal Vol.22 No.1 (2023)
Suggested Citation
Kotepui M., Kotepui K.U., Masangkay F.R., Wilairatana P. Evidence of malarial chemoprophylaxis among travellers who died from malaria: a systematic review and meta-analysis. Malaria Journal Vol.22 No.1 (2023). doi:10.1186/s12936-023-04794-x Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91270
Title
Evidence of malarial chemoprophylaxis among travellers who died from malaria: a systematic review and meta-analysis
Author(s)
Other Contributor(s)
Abstract
Background: Chemoprophylaxis is a prevention method for malaria during travel in malaria-endemic countries. This study aimed to collate and synthesize the evidence of malarial chemoprophylaxis among malaria death cases. Methods: Studies documenting malarial chemoprophylaxis related to malaria deaths were searched in PubMed, Scopus, MEDLINE, Embase, and CENTRAL until 3 July 2022. The pooled proportion of malarial chemoprophylaxis among death cases was synthesized using logit transformation and back transformation to a proportion performed using generalized linear mixed models. The pooled log odds ratio (log-OR) with a 95% confidence interval (CI) of malarial chemoprophylaxis in death cases compared to survivors were synthesized. Results: Fifty-eight studies were included in the systematic review and the meta-analysis. Of 602 pooled malaria death cases, the number of patients who took chemoprophylaxis was 187 (30%) (95% CI 22–40, P < 0.01, 58 studies), and those who took adequate chemoprophylaxis were 24 (5%) (95% CI 2–13, P < 0.01, 42 studies). A comparable log-OR of underwent chemoprophylaxis was observed between malaria death cases and survivors (P = 0.94, pooled log-OR: − 0.02, 95% CI − 0.46–0.42, I2: 0%, 17 studies). Similarly, a comparable log-OR of adequate chemoprophylaxis was identified between malaria death cases and survivors (P = 0.15, pooled log-OR: 0.83, 95% CI − 0.30–1.97, I2: 47.08%, 11 studies). Conclusions: Among the studies where malarial chemoprophylaxis was reported, approximately 30% of malaria death cases had taken such prophylaxis. Notably, only 5% of these cases adhered fully or adequately to the recommended chemoprophylactic regimen. However, the analysis did not reveal a significant difference in the odds of malarial chemoprophylaxis between malaria death cases and survivors.