Usefulness of Ultrasound Shear Wave Elastography for Detection of Quadriceps Contracture in Immobilized Rats
Issued Date
2024-01-01
Resource Type
eISSN
20762615
Scopus ID
2-s2.0-85181875336
Journal Title
Animals
Volume
14
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Animals Vol.14 No.1 (2024)
Suggested Citation
Suwankanit K., Shimizu M., Suzuki K., Kaneda M. Usefulness of Ultrasound Shear Wave Elastography for Detection of Quadriceps Contracture in Immobilized Rats. Animals Vol.14 No.1 (2024). doi:10.3390/ani14010076 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95948
Title
Usefulness of Ultrasound Shear Wave Elastography for Detection of Quadriceps Contracture in Immobilized Rats
Author(s)
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Quadriceps contracture is an abnormal pathological shortening of the muscle–tendon unit. To improve the prognosis of quadriceps contracture, improvement of its diagnostic method is needed. In this study, we evaluated the diagnostic utility of ultrasound shear wave elastography in a rat model of quadriceps contracture induced by immobilization. Fifty Wistar rats were randomly divided into control and immobilization groups. During up to 4 weeks of joint immobilization, the quadriceps elastic modulus, muscle hardness, creatinine phosphokinase levels, joint range of motion, histopathologic parameters, and levels of fibrosis-associated mRNA expression were measured every week in the immobilization and control groups and compared. In the immobilization group, the elastic modulus gradually but significantly increased (p < 0.05) throughout the immobilization period. However, muscle hardness and serum creatinine phosphokinase levels only increased at 1 and 2 weeks after the start of immobilization, respectively. Muscle atrophy and shortening progressed throughout the immobilization group. Collagen type I and III, α-SMA protein, and mRNA expression of IL-1β and TGF-β1 significantly increased (p < 0.05) throughout in the immobilization group. Ultrasound shear wave elastography is the most useful method for clinical assessment of muscle contracture.