Analysis of Dermal Thickness Across 10 Areas and Injection Depth After Polynucleotide Injection Using Rejumate Automatic 0.8-mm 9-pin Injector on the Face Using 33-MHz Sonography
Issued Date
2025-01-01
Resource Type
eISSN
21697574
Scopus ID
2-s2.0-105034430494
Journal Title
Plastic and Reconstructive Surgery Global Open
Volume
13
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Plastic and Reconstructive Surgery Global Open Vol.13 No.9 (2025)
Suggested Citation
Kim J.S., Atchima S. Analysis of Dermal Thickness Across 10 Areas and Injection Depth After Polynucleotide Injection Using Rejumate Automatic 0.8-mm 9-pin Injector on the Face Using 33-MHz Sonography. Plastic and Reconstructive Surgery Global Open Vol.13 No.9 (2025). doi:10.1097/GOX.0000000000007121 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116067
Title
Analysis of Dermal Thickness Across 10 Areas and Injection Depth After Polynucleotide Injection Using Rejumate Automatic 0.8-mm 9-pin Injector on the Face Using 33-MHz Sonography
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Corresponding Author(s)
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Abstract
Background: – Automated injection devices are becoming essential tools in aesthetic medicine, offering precision and consistency in treatments such as polynucleotide (PN) injections for skin rejuvenation. This study aimed to analyze the dermal thickness across facial regions and evaluate the consistency of injection depth achieved with the Rejumate automatic injector. Methods: – A total of 31 patients (average age 48.2 y; 4 men and 27 women) underwent dermal thickness measurements using high-resolution 33-MHz ultrasound in 11 facial regions, including the forehead, temple, orbital rim, lower eyelid, malar, anterior cheek, lateral cheek, posterior cheek, jawline, and chin. Each patient then received a standardized 2-mL PN injection using the Rejumate injector with a 0.8-mm needle across 317 individual points. Injection depth, distribution, and consistency were measured and analyzed. Results: – The average dermal thickness across regions ranged from 0.53 (lower eyelid) to 1.18 mm (temple and posterior cheek). The Rejumate injector demonstrated a high degree of consistency, achieving an average injection depth of 0.55 mm (SD = 0.13 mm), with a median depth of 0.54 mm. The depth range (0.29–0.99 mm) and interquartile range (0.17 mm) indicated controlled depth with minimal variability. Conclusions: – The Rejumate automatic injector reliably delivers PN at a controlled depth, showing minimal variability across injections. This precision supports improved safety and efficacy in PN delivery, providing a valuable reference for clinical application in aesthetic treatments. Given the anatomical differences in dermal thickness across facial regions, this standardized approach may optimize outcomes and increase patient satisfaction.