Watson J.A., White N.J., Dondorp A.M. Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era. Trends in Parasitology Vol.38 No.1 (2022) , 11-14. 14. doi:10.1016/j.pt.2021.10.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85064
Title
Falciparum malaria mortality in sub-Saharan Africa in the pretreatment era
Driven by the malaria-protective effect of sickle-cell trait, balancing selection results in hemoglobin S equilibrium allele frequencies of between 15% and 20% in areas of high Plasmodium falciparum transmission in sub-Saharan Africa. From this we estimate that the malaria-attributable childhood mortality in the pretreatment era was between 15% and 24%.
