Effects of AGT and AGTR1 Genetic Polymorphisms and Changes in Blood Pressure Over a Five-Year Follow-Up
Issued Date
2023-01-01
Resource Type
eISSN
11791594
Scopus ID
2-s2.0-85180824248
Journal Title
Risk Management and Healthcare Policy
Volume
16
Start Page
2931
End Page
2942
Rights Holder(s)
SCOPUS
Bibliographic Citation
Risk Management and Healthcare Policy Vol.16 (2023) , 2931-2942
Suggested Citation
Chaimati S., Shantavasinkul P.C., Sirivarasai J., Sritara P. Effects of AGT and AGTR1 Genetic Polymorphisms and Changes in Blood Pressure Over a Five-Year Follow-Up. Risk Management and Healthcare Policy Vol.16 (2023) , 2931-2942. 2942. doi:10.2147/RMHP.S442983 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/95906
Title
Effects of AGT and AGTR1 Genetic Polymorphisms and Changes in Blood Pressure Over a Five-Year Follow-Up
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Abstract
Purpose: The renin–angiotensin system plays an important role in the central regulation of blood pressure (BP). Genetic variations of angiotensinogen (AGT) and angiotensin II type 1 receptor (AGTR1) may increase susceptibility to elevated BP and hypertension. This study investigated the effects of AGT rs699 and AGTR1 rs5186 single nucleotide polymorphisms (SNPs) on BP at baseline and at a 5-year follow-up. Paticipants and Methods: The study population consisted of participants from the Electricity Generating Authority of Thailand cohort study (n=354); data were collected at baseline (2013) and 5 years later (2018). Genotyping of the two SNPs was performed using TaqMan® assay and statistical analyses were performed with SNPStats software. Results: The frequencies of the two SNPs were within the Hardy–Weinberg equilibrium (p=0.22 for AGT rs699 and p=0.06 for AGTR1 rs5186). For each SNP, mutant genotypes were significantly associated with increased systolic BP and/or diastolic BP in the codominant and recessive models. Risk alleles of AGT rs699 and AGTR1 rs5186 were associated with increased odds of hypertension and hypertension with metabolic syndrome at follow-up. Conclusion: Overall, our results suggest that polymorphisms of genes in the renin–angiotensin system increase susceptibility to the development and progression of hypertension and the development of the metabolic syndrome.