Pre-Op Hydronephrosis Predicts Outcomes in Patients Receiving Robot-Assisted Radical Cystectomy
Issued Date
2024-08-01
Resource Type
eISSN
20726694
Scopus ID
2-s2.0-85202463084
Journal Title
Cancers
Volume
16
Issue
16
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cancers Vol.16 No.16 (2024)
Suggested Citation
Wong C.H.M., Ko I.C.H., Leung D.K.W., Kang S.H., Kitamura K., Horie S., Muto S., Ohyama C., Hatakeyama S., Patel M., Yang C.K., Kijvikai K., Lee J.Y., Chen H.G., Zhang R.Y., Lin T.X., Lee L.S., Teoh J.Y.C., Chan E. Pre-Op Hydronephrosis Predicts Outcomes in Patients Receiving Robot-Assisted Radical Cystectomy. Cancers Vol.16 No.16 (2024). doi:10.3390/cancers16162826 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100972
Title
Pre-Op Hydronephrosis Predicts Outcomes in Patients Receiving Robot-Assisted Radical Cystectomy
Author's Affiliation
Sengkang General Hospital
Korea University Anam Hospital
Ramathibodi Hospital
Juntendo University Graduate School of Medicine
Renji Hospital
Chinese University of Hong Kong, Faculty of Medicine
Hirosaki University
The University of Sydney
Sun Yat-Sen University
Medizinische Universität Wien
Veterans General Hospital-Taichung Taiwan
The Catholic University of Korea
Chinese University of Hong Kong
Korea University Anam Hospital
Ramathibodi Hospital
Juntendo University Graduate School of Medicine
Renji Hospital
Chinese University of Hong Kong, Faculty of Medicine
Hirosaki University
The University of Sydney
Sun Yat-Sen University
Medizinische Universität Wien
Veterans General Hospital-Taichung Taiwan
The Catholic University of Korea
Chinese University of Hong Kong
Corresponding Author(s)
Other Contributor(s)
Abstract
Introduction: Robot-assisted radical cystectomy (RARC) has gained momentum in the management of muscle invasive bladder cancer (MIBC). Predictors of RARC outcomes are not thoroughly studied. We aim to investigate the implications of preoperative hydronephrosis on oncological outcomes. Patients and Methods: This study analysed data from the Asian RARC consortium, a multicentre registry involving nine Asian centres. Cases were divided into two groups according to the presence or absence of pre-operative hydronephrosis. Background characteristics, operative details, perioperative outcomes, and oncological results were reviewed. Outcomes were (1) survival outcomes, including 10-year disease-free survival (DFS) and overall survival (OS), and (2) perioperative and pathological results. Multivariate regression analyses were performed on survival outcomes. Results: From 2007 to 2020, 536 non-metastatic MIBC patients receiving RARC were analysed. 429 had no hydronephrosis (80.0%), and 107 (20.0%) had hydronephrosis. Hydronephrosis was found to be predictive of inferior DFS (HR = 1.701, p = 0.003, 95% CI = 1.196–2.418) and OS (HR = 1.834, p = 0.008, 95% CI = 1.173–2.866). Subgroup analysis demonstrated differences in the T2-or-above subgroup (HR = 1.65; p = 0.004 in DFS and HR = 1.888; p = 0.008 in OS) and the T3-or-above subgroup (HR = 1.757; p = 0.017 in DFS and HR = 1.807; p = 0.034 in OS). Conclusions: The presence of preoperative hydronephrosis among MIBC patients carries additional prognostic implications on top of tumour staging. Its importance in case selection needs to be highlighted.