Compulsive-like eating of high-fat high-sugar food is associated with ‘addiction-like’ glutamatergic dysfunction in obesity prone rats
5
Issued Date
2022-09-01
Resource Type
ISSN
13556215
eISSN
13691600
Scopus ID
2-s2.0-85136523709
Pubmed ID
36001420
Journal Title
Addiction Biology
Volume
27
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
Addiction Biology Vol.27 No.5 (2022)
Suggested Citation
Sketriene D., Battista D., Lalert L., Kraiwattanapirom N., Thai H.N., Leeboonngam T., Knackstedt L.A., Nithianantharajah J., Sumithran P., Lawrence A.J., Brown R.M. Compulsive-like eating of high-fat high-sugar food is associated with ‘addiction-like’ glutamatergic dysfunction in obesity prone rats. Addiction Biology Vol.27 No.5 (2022). doi:10.1111/adb.13206 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85579
Title
Compulsive-like eating of high-fat high-sugar food is associated with ‘addiction-like’ glutamatergic dysfunction in obesity prone rats
Other Contributor(s)
Abstract
Chronic overeating is a core feature of diet-induced obesity. There is increasing evidence that in vulnerable individuals, such overeating could become compulsive, resembling an addictive disorder. The transition to compulsive substance use has been linked with changes at glutamatergic synapses in the nucleus accumbens. In this study, we investigated a potential link between such glutamatergic dysregulation and compulsive-like eating using a rat model of diet-induced obesity. A conditioned suppression task demonstrated that diet-induced obese rats display eating despite negative consequences, as their consumption was insensitive to an aversive cue. Moreover, nucleus accumbens expression of GluA1 and xCT proteins was upregulated in diet-induced obese animals. Lastly, both a computed ‘addiction score’ (based on performance across three criteria) and weight gain were positively correlated with changes in GluA1 and xCT expression in the nucleus accumbens. These data demonstrate that the propensity for diet-induced obesity is associated with compulsive-like eating of highly palatable food and is accompanied by ‘addiction-like’ glutamatergic dysregulation in the nucleus accumbens, thus providing neurobiological evidence of addiction-like pathology in this model of obesity.