Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
Issued Date
2024-05-01
Resource Type
eISSN
14761645
Scopus ID
2-s2.0-85192112589
Pubmed ID
38507807
Journal Title
The American journal of tropical medicine and hygiene
Volume
110
Issue
5
Start Page
994
End Page
998
Rights Holder(s)
SCOPUS
Bibliographic Citation
The American journal of tropical medicine and hygiene Vol.110 No.5 (2024) , 994-998
Suggested Citation
Yimthin T., Phunpang R., Wright S.W., Thiansukhon E., Chaisuksant S., Chetchotisakd P., Tanwisaid K., Chuananont S., Morakot C., Sangsa N., Silakun W., Chayangsu S., Buasi N., Lertmemongkolchai G., Chantratita N., West T.E. Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients. The American journal of tropical medicine and hygiene Vol.110 No.5 (2024) , 994-998. 998. doi:10.4269/ajtmh.23-0381 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98311
Title
Lack of Association of TLR1 and TLR5 Coding Variants with Mortality in a Large Multicenter Cohort of Melioidosis Patients
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
Mahidol Oxford Tropical Medicine Research Unit
Vetsuisse-Fakultät
Udon Thani Center Hospital
University of Washington School of Medicine
Surin Hospital
University of Bern
Khon Kaen University
University of Washington
Khon Kaen Regional Hospital
Chiang Mai University
Nakhon Phanom Hospital
Buriram Hospital
Sisaket Hospital
Roi Et Hospital
Mukdahan Hospital
Mahidol Oxford Tropical Medicine Research Unit
Vetsuisse-Fakultät
Udon Thani Center Hospital
University of Washington School of Medicine
Surin Hospital
University of Bern
Khon Kaen University
University of Washington
Khon Kaen Regional Hospital
Chiang Mai University
Nakhon Phanom Hospital
Buriram Hospital
Sisaket Hospital
Roi Et Hospital
Mukdahan Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Melioidosis, infection caused by Burkholderia pseudomallei, is characterized by robust innate immune responses. We have previously reported associations of TLR1 single nucleotide missense variant rs76600635 with mortality and of TLR5 nonsense variant rs5744168 with both bacteremia and mortality in single-center studies of patients with melioidosis in northeastern Thailand. The objective of this study was to externally validate the associations of rs76600635 and rs5744168 with bacteremia and mortality in a large multicenter cohort of melioidosis patients. We genotyped rs76600635 and rs5744168 in 1,338 melioidosis patients enrolled in a prospective parent cohort study conducted at nine hospitals in northeastern Thailand. The genotype frequencies of rs76600635 did not differ by bacteremia status (P = 0.27) or 28-day mortality (P = 0.84). The genotype frequencies of rs5744168 did not differ by either bacteremia status (P = 0.46) or 28-day mortality (P = 0.10). Assuming a dominant genetic model, there was no association of the rs76600635 variant with bacteremia (adjusted odds ratio [OR], 0.75; 95% CI, 0.54-1.04, P = 0.08) or 28-day mortality (adjusted OR, 0.96; 95% CI, 0.71-1.28, P = 0.77). There was no association of the rs5744168 variant with bacteremia (adjusted OR, 1.24; 95% CI, 0.76-2.03, P = 0.39) or 28-day mortality (adjusted OR, 1.22; 95% CI, 0.83-1.79, P = 0.21). There was also no association of either variant with 1-year mortality. We conclude that in a large multicenter cohort of patients hospitalized with melioidosis in northeastern Thailand, neither TLR1 missense variant rs76600635 nor TLR5 nonsense variant rs5744168 is associated with bacteremia or mortality.