Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil
Issued Date
2022-09-01
Resource Type
eISSN
2215017X
Scopus ID
2-s2.0-85135298747
Journal Title
Biotechnology Reports
Volume
35
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biotechnology Reports Vol.35 (2022)
Suggested Citation
Barbosa A.G.R., Tintino C.D.M.O., Pessoa R.T., de Lacerda Neto L.J., Martins A.O.B.P.B., de Oliveira M.R.C., Coutinho H.D.M., Cruz-Martins N., Quintans Junior L.J., Wilairatana P., de Menezes I.R.A. Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil. Biotechnology Reports Vol.35 (2022). doi:10.1016/j.btre.2022.e00756 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/83629
Title
Anti-inflammatory and antinociceptive effect of Hyptis martiusii BENTH leaves essential oil
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal
Instituto Universitário de Ciências da Saúde (IUCS)
Cooperativa de Ensino Superior, Politécnico e Universitário
Universidade Estadual do Ceará
Faculdade de Medicina da Universidade do Porto (FMUP)
Universidade Regional do Cariri
Universidade Federal de Sergipe
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal
Instituto Universitário de Ciências da Saúde (IUCS)
Cooperativa de Ensino Superior, Politécnico e Universitário
Universidade Estadual do Ceará
Faculdade de Medicina da Universidade do Porto (FMUP)
Universidade Regional do Cariri
Universidade Federal de Sergipe
Other Contributor(s)
Abstract
Hyptis martiusii Benth. also known as "cidreira brava", has some activities verified in the literature, such as antiulcerogenic, antimicrobial and antiedematogenic. This study aimed to verify the anti-inflammatory and antinociceptive effect of the leaves essential oil. For the evaluation of the anti-inflammatory activity of OEHM (100 mg/kg/p.o.), models paw edema induced by dextran and histamine, peritonitis and vascular permeability were used. Regarding the anti-nociceptive activity of the OEHM, abdominal contortion tests by acetic acid, formalin, hot plate (50.75 and 100 mg/kg/p.o.), open field and mechanical plantar hyper-nociception (100 mg/kg/p.o.) were carried out. OEHM (100 mg/kg) showed anti-inflammatory activity, being able to remarkably deducing the paw edema induced by dextran and histamine, the total number of cell leukocytes/neutrophils in peritonitis, and exudate in vascular permeability. In antinociceptive activity, the OEHM did not promote significant effect in central nervous system in the open field assay, remarkably reduced abdominal contortions (50, 75 and 100 mg/kg), the time in the formalin assay and the mechanical hyper-nociception (100 mg/kg); however, only doses between 75 and 100 mg/kg were capable of ameliorating the reponse latency time. Regarding the probable mechanism of action, the antinociceptive activity includes the participation in the activation of opioid, TRPV1, and α2-noradrenergic systems. In short, data obtained here reveal that OEHM has anti-inflammatory and antinociceptive activity, implying that its action may be involved in the mechanism of inhibition or liberation of pro-inflammatory mediators involved in pain and inflammation.