Long-term treatment outcomes of pediatric low-grade gliomas treated at a university-based hospital
Issued Date
2023-05-01
Resource Type
ISSN
02567040
eISSN
14330350
Scopus ID
2-s2.0-85144833210
Pubmed ID
36574012
Journal Title
Child's Nervous System
Volume
39
Issue
5
Start Page
1173
End Page
1182
Rights Holder(s)
SCOPUS
Bibliographic Citation
Child's Nervous System Vol.39 No.5 (2023) , 1173-1182
Suggested Citation
Jujui-eam A., Sirachainan N., Hongeng S., Hansasuta A., Boongird A., Tritanon O., Dhanachai M., Swangsilpa T., Ruangkanchanasetr R., Worawongsakul R., Puataweepong P. Long-term treatment outcomes of pediatric low-grade gliomas treated at a university-based hospital. Child's Nervous System Vol.39 No.5 (2023) , 1173-1182. 1182. doi:10.1007/s00381-022-05809-9 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82064
Title
Long-term treatment outcomes of pediatric low-grade gliomas treated at a university-based hospital
Author's Affiliation
Other Contributor(s)
Abstract
Purpose: A multimodality approach is generally considered for pediatric low-grade gliomas (LGG); however, the optimal management remains uncertain. The objective of the study was to evaluate treatment outcomes of pediatric LGG, focusing on long-term survival and factors related to outcomes. Methods: A retrospective review of 77 pediatric LGG cases treated at Ramathibodi Hospital, Thailand between 2000 and 2018 was performed. The inclusion criteria were all pediatric LGG cases aged ≤ 15 years. Diffuse intrinsic pontine gliomas and spinal cord tumors were excluded. Results: The median follow-up time was 8.2 years (range, 0.6–19.7). The median age at diagnosis was 6.2 years (interquartile range, 3.6–11.4). Treatments modality included tumor surgery (93%), chemotherapy (40%), and radiation therapy (14%). The 10-year overall survival (OS) and 10-year progression-free survival were 94% and 59%, respectively, for the entire cohort. The 10-year OS was 100% in three subgroups of patients: pilocytic subtype, WHO grade 1 tumors, and recipient of gross total resection. After multivariable analysis, no tumor surgery had a significantly unfavorable influence on overall survival. Conclusions: With a multimodality approach, pediatric LGGs had excellent outcome. Gross total resection is the standard primary treatment. Chemotherapy is the alternative standard treatment in incomplete resection cases, unresectable patients, or patients with progressive disease. Radiation therapy should be reserved as a salvage treatment option because of late complications that usually affect patients’ quality of life.