The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019
Issued Date
2023-01-01
Resource Type
ISSN
23742437
eISSN
23742445
Scopus ID
2-s2.0-85174335406
Pubmed ID
37676656
Journal Title
JAMA Oncology
Rights Holder(s)
SCOPUS
Bibliographic Citation
JAMA Oncology (2023)
Suggested Citation
Da Cunha A.R., Compton K., Xu R., Mishra R., Drangsholt M.T., Antunes J.L.F., Kerr A.R., Acheson A.R., Lu D., Wallace L.E., Kocarnik J.M., Fu W., Dean F.E., Pennini A., Henrikson H.J., Alam T., Ababneh E., Abd-Elsalam S., Abdoun M., Abidi H., Abubaker Ali H., Abu-Gharbieh E., Adane T.D., Addo I.Y., Ahmad A., Ahmad S., Ahmed Rashid T., Akonde M., Al Hamad H., Alahdab F., Alimohamadi Y., Alipour V., Al-Maweri S.A., Alsharif U., Ansari-Moghaddam A., Anwar S.L., Anyasodor A.E., Arabloo J., Aravkin A.Y., Aruleba R.T., Asaad M., Ashraf T., Athari S.S., Attia S., Azadnajafabad S., Azangou-Khyavy M., Badar M., Baghcheghi N., Banach M., Bardhan M., Barqawi H.J., Bashir N.Z., Bashiri A., Benzian H., Bernabe E., Bhagat D.S., Bhojaraja V.S., Bjørge T., Bouaoud S., Braithwaite D., Briko N.I., Calina D., Carreras G., Chakraborty P.A., Chattu V.K., Chaurasia A., Chen M.X., Cho W.C.S., Chu D.T., Chukwu I.S., Chung E., Cruz-Martins N., Dadras O., Dai X., Dandona L., Dandona R., Daneshpajouhnejad P., Darvishi Cheshmeh Soltani R., Darwesh A.M., Debela S.A., Derbew Molla M., Dessalegn F.N., Dianati-Nasab M., Digesa L.E., Dixit S.G., Dixit A., Djalalinia S., El Sayed I., El Tantawi M., Enyew D.B., Erku D.A., Ezzeddini R., Fagbamigbe A.F., Falzone L., Fetensa G., Fukumoto T., Gaewkhiew P., Gallus S., Gebrehiwot M., Ghashghaee A. The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019. JAMA Oncology (2023). doi:10.1001/jamaoncol.2023.2960 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90796
Title
The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019
Author(s)
Da Cunha A.R.
Compton K.
Xu R.
Mishra R.
Drangsholt M.T.
Antunes J.L.F.
Kerr A.R.
Acheson A.R.
Lu D.
Wallace L.E.
Kocarnik J.M.
Fu W.
Dean F.E.
Pennini A.
Henrikson H.J.
Alam T.
Ababneh E.
Abd-Elsalam S.
Abdoun M.
Abidi H.
Abubaker Ali H.
Abu-Gharbieh E.
Adane T.D.
Addo I.Y.
Ahmad A.
Ahmad S.
Ahmed Rashid T.
Akonde M.
Al Hamad H.
Alahdab F.
Alimohamadi Y.
Alipour V.
Al-Maweri S.A.
Alsharif U.
Ansari-Moghaddam A.
Anwar S.L.
Anyasodor A.E.
Arabloo J.
Aravkin A.Y.
Aruleba R.T.
Asaad M.
Ashraf T.
Athari S.S.
Attia S.
Azadnajafabad S.
Azangou-Khyavy M.
Badar M.
Baghcheghi N.
Banach M.
Bardhan M.
Barqawi H.J.
Bashir N.Z.
Bashiri A.
Benzian H.
Bernabe E.
Bhagat D.S.
Bhojaraja V.S.
Bjørge T.
Bouaoud S.
Braithwaite D.
Briko N.I.
Calina D.
Carreras G.
Chakraborty P.A.
Chattu V.K.
Chaurasia A.
Chen M.X.
Cho W.C.S.
Chu D.T.
Chukwu I.S.
Chung E.
Cruz-Martins N.
Dadras O.
Dai X.
Dandona L.
Dandona R.
Daneshpajouhnejad P.
Darvishi Cheshmeh Soltani R.
Darwesh A.M.
Debela S.A.
Derbew Molla M.
Dessalegn F.N.
Dianati-Nasab M.
Digesa L.E.
Dixit S.G.
Dixit A.
Djalalinia S.
El Sayed I.
El Tantawi M.
Enyew D.B.
Erku D.A.
Ezzeddini R.
Fagbamigbe A.F.
Falzone L.
Fetensa G.
Fukumoto T.
Gaewkhiew P.
Gallus S.
Gebrehiwot M.
Ghashghaee A.
Compton K.
Xu R.
Mishra R.
Drangsholt M.T.
Antunes J.L.F.
Kerr A.R.
Acheson A.R.
Lu D.
Wallace L.E.
Kocarnik J.M.
Fu W.
Dean F.E.
Pennini A.
Henrikson H.J.
Alam T.
Ababneh E.
Abd-Elsalam S.
Abdoun M.
Abidi H.
Abubaker Ali H.
Abu-Gharbieh E.
Adane T.D.
Addo I.Y.
Ahmad A.
Ahmad S.
Ahmed Rashid T.
Akonde M.
Al Hamad H.
Alahdab F.
Alimohamadi Y.
Alipour V.
Al-Maweri S.A.
Alsharif U.
Ansari-Moghaddam A.
Anwar S.L.
Anyasodor A.E.
Arabloo J.
Aravkin A.Y.
Aruleba R.T.
Asaad M.
Ashraf T.
Athari S.S.
Attia S.
Azadnajafabad S.
Azangou-Khyavy M.
Badar M.
Baghcheghi N.
Banach M.
Bardhan M.
Barqawi H.J.
Bashir N.Z.
Bashiri A.
Benzian H.
Bernabe E.
Bhagat D.S.
Bhojaraja V.S.
Bjørge T.
Bouaoud S.
Braithwaite D.
Briko N.I.
Calina D.
Carreras G.
Chakraborty P.A.
Chattu V.K.
Chaurasia A.
Chen M.X.
Cho W.C.S.
Chu D.T.
Chukwu I.S.
Chung E.
Cruz-Martins N.
Dadras O.
Dai X.
Dandona L.
Dandona R.
Daneshpajouhnejad P.
Darvishi Cheshmeh Soltani R.
Darwesh A.M.
Debela S.A.
Derbew Molla M.
Dessalegn F.N.
Dianati-Nasab M.
Digesa L.E.
Dixit S.G.
Dixit A.
Djalalinia S.
El Sayed I.
El Tantawi M.
Enyew D.B.
Erku D.A.
Ezzeddini R.
Fagbamigbe A.F.
Falzone L.
Fetensa G.
Fukumoto T.
Gaewkhiew P.
Gallus S.
Gebrehiwot M.
Ghashghaee A.
Author's Affiliation
Faculty of Dentistry
University of Kurdistan Hewlêr
College of Medicine, University of Ibadan
IUMS Health Management and Economics Research Center
Public Health Foundation of India
University of Florida Health
University of Human Development
Non-Communicable Diseases Research Center
Wollega University
Sage Bionetworks
Western Norway University of Applied Sciences
Shaqra University
Wollo University
Madda Walabu University
Arba Minch University
Saveetha Medical College and Hospital
All India Institute of Medical Sciences, Jodhpur
NYU College of Dentistry
Saveh University of Medical Sciences
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal
Datta Meghe Institute of Higher Education & Research (Deemed to be University)
Institute for Health Metrics and Evaluation
Mahidol University, Faculty of Dentistry
Cancer Institute NSW
University of Gondar
Qatar University
Rumailah Hospital
Hamad Medical Corporation
Instytut Centrum Zdrowia Matki Polki
Vietnam National University, Hanoi
Haramaya University
University of Sharjah
University of Lahore
Universitas Gadjah Mada
Université Ferhat Abbas Sétif 1
Gomal University
Yasuj University of Medical Sciences
Alexandria University
Griffith University
Tarbiat Modares University
Federal Medical Centre Nigeria
Arak University of Medical Sciences
Zahedan University of Medical Sciences
Universitetet i Bergen
Istituto di Ricerche Farmacologiche Mario Negri
Cancer Registry of Norway
University of Washington School of Medicine
UNSW Sydney
University of Texas Health Science Center at Houston
Qazvin University of Medical Sciences
Indian Council of Medical Research
University of California, Berkeley
Iran University of Medical Sciences
University of British Columbia, Faculty of Medicine
Shiraz University of Medical Sciences
King George's Medical University
Cleveland Clinic Foundation
Isfahan University of Medical Sciences
Shahid Beheshti University of Medical Sciences
Universiteit Maastricht
School of Public Health
University of South Carolina
Istituto Nazionale Tumori IRCCS - Fondazione G Pascale, Napoli
Justus-Liebig-Universität Gießen
University of Aberdeen
University of Washington
University of Bristol, Faculty of Health Sciences
Queen Elizabeth Hospital Hong Kong
Zanjan University of Medical Sciences (ZUMS)
King's College London
Kobe University
The University of British Columbia
Sechenov First Moscow State Medical University
Università degli Studi di Catania
Rijksuniversiteit Groningen
Baqiyatallah University of Medical Sciences
Universidade de São Paulo
National Institute of Cholera and Enteric Diseases India
University of Florida College of Medicine
Iranian Ministry of Health and Medical Education
Medical University of Lodz
Johns Hopkins Medicine
Mayo Clinic
Universitatea de Medicină şi Farmacie din Craiova
Charles Sturt University
Faculty of Medicine
University of Cape Town
University of Bahrain
Polytechnic and University Higher Education Cooperative
Abasyn University
Salale University
Prevention and Clinical Network
University Hospital Saadna Abdenour
Government Institute of Forensic Science
Dortmund Clinic
University of Kurdistan Hewlêr
College of Medicine, University of Ibadan
IUMS Health Management and Economics Research Center
Public Health Foundation of India
University of Florida Health
University of Human Development
Non-Communicable Diseases Research Center
Wollega University
Sage Bionetworks
Western Norway University of Applied Sciences
Shaqra University
Wollo University
Madda Walabu University
Arba Minch University
Saveetha Medical College and Hospital
All India Institute of Medical Sciences, Jodhpur
NYU College of Dentistry
Saveh University of Medical Sciences
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal
Datta Meghe Institute of Higher Education & Research (Deemed to be University)
Institute for Health Metrics and Evaluation
Mahidol University, Faculty of Dentistry
Cancer Institute NSW
University of Gondar
Qatar University
Rumailah Hospital
Hamad Medical Corporation
Instytut Centrum Zdrowia Matki Polki
Vietnam National University, Hanoi
Haramaya University
University of Sharjah
University of Lahore
Universitas Gadjah Mada
Université Ferhat Abbas Sétif 1
Gomal University
Yasuj University of Medical Sciences
Alexandria University
Griffith University
Tarbiat Modares University
Federal Medical Centre Nigeria
Arak University of Medical Sciences
Zahedan University of Medical Sciences
Universitetet i Bergen
Istituto di Ricerche Farmacologiche Mario Negri
Cancer Registry of Norway
University of Washington School of Medicine
UNSW Sydney
University of Texas Health Science Center at Houston
Qazvin University of Medical Sciences
Indian Council of Medical Research
University of California, Berkeley
Iran University of Medical Sciences
University of British Columbia, Faculty of Medicine
Shiraz University of Medical Sciences
King George's Medical University
Cleveland Clinic Foundation
Isfahan University of Medical Sciences
Shahid Beheshti University of Medical Sciences
Universiteit Maastricht
School of Public Health
University of South Carolina
Istituto Nazionale Tumori IRCCS - Fondazione G Pascale, Napoli
Justus-Liebig-Universität Gießen
University of Aberdeen
University of Washington
University of Bristol, Faculty of Health Sciences
Queen Elizabeth Hospital Hong Kong
Zanjan University of Medical Sciences (ZUMS)
King's College London
Kobe University
The University of British Columbia
Sechenov First Moscow State Medical University
Università degli Studi di Catania
Rijksuniversiteit Groningen
Baqiyatallah University of Medical Sciences
Universidade de São Paulo
National Institute of Cholera and Enteric Diseases India
University of Florida College of Medicine
Iranian Ministry of Health and Medical Education
Medical University of Lodz
Johns Hopkins Medicine
Mayo Clinic
Universitatea de Medicină şi Farmacie din Craiova
Charles Sturt University
Faculty of Medicine
University of Cape Town
University of Bahrain
Polytechnic and University Higher Education Cooperative
Abasyn University
Salale University
Prevention and Clinical Network
University Hospital Saadna Abdenour
Government Institute of Forensic Science
Dortmund Clinic
Other Contributor(s)
Abstract
Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence Review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370000 (95% uncertainty interval [UI], 338000-401000) cases and 199000 (95% UI, 181000-217000) deaths for LOC and 167000 (95% UI, 153000-180000) cases and 114000 (95% UI, 103000-126000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and Relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts..