Efficacy and safety of stem cell-based interventions for burn wound healing: A systematic review and meta-analysis of pre-clinical and early clinical evidence
Issued Date
2026-03-01
Resource Type
ISSN
19054637
eISSN
30277922
Scopus ID
2-s2.0-105034424095
Journal Title
Thai Journal of Pharmaceutical Sciences
Volume
50
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Thai Journal of Pharmaceutical Sciences Vol.50 No.1 (2026)
Suggested Citation
Poowaruttanawiwit P., Kulla P., Pakpoomkamonlert N. Efficacy and safety of stem cell-based interventions for burn wound healing: A systematic review and meta-analysis of pre-clinical and early clinical evidence. Thai Journal of Pharmaceutical Sciences Vol.50 No.1 (2026). doi:10.56808/3027-7922.3144 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/116093
Title
Efficacy and safety of stem cell-based interventions for burn wound healing: A systematic review and meta-analysis of pre-clinical and early clinical evidence
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Author's Affiliation
Corresponding Author(s)
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Abstract
Background: Burn injuries remain a major therapeutic challenge, with conventional treatments often failing to achieve complete functional skin regeneration. Stem cell-based interventions, including mesenchymal stem cells (MSCs) and exosome derivatives, have demonstrated regenerative and immunomodulatory potential, yet their translation to clinical practice remains limited. Objectives: To systematically evaluate the efficacy and safety of stem cell-based therapies for burn wound healing across pre-clinical and clinical studies. Materials and Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, four databases (PubMed, Embase, Scopus, and Cochrane) were searched through April 2025. Eligible studies included randomized controlled trials and controlled pre-clinical studies comparing stem cell-based interventions with standard care or placebo. Risk of bias (RoB) was assessed using RoB 2 and the Systematic Review Centre for Laboratory Animal Experimentation tools, and evidence certainty was rated using GRADE. Results: Four studies met the inclusion criteria: One early-phase clinical trial and two pre-clinical randomized studies (MSC extract and exosome therapy). Pooled analysis of pre-clinical data showed a moderate-to-large effect favoring stem cell interventions (standardized mean difference = 1.15; 95% confidence interval 0.54–1.76; I<sup>2</sup> = 49.4%). Certainty of evidence was moderate for efficacy and low for safety. Conclusion: Stem cell-based therapies suggest potential benefit in enhancing burn wound healing, yet the evidence remains preliminary and largely pre-clinical. These interventions should be regarded as investigational, pending well-powered multicenter clinical trials with standardized protocols and long-term safety evaluation.