Prevalence, Risk Factors, and Prognosis of Liver Involvement in Adult Patients with Chikungunya in Thailand
Issued Date
2022-11-14
Resource Type
eISSN
14761645
Scopus ID
2-s2.0-85142402212
Pubmed ID
36252802
Journal Title
The American journal of tropical medicine and hygiene
Volume
107
Issue
5
Start Page
1107
End Page
1113
Rights Holder(s)
SCOPUS
Bibliographic Citation
The American journal of tropical medicine and hygiene Vol.107 No.5 (2022) , 1107-1113
Suggested Citation
Srikirin P., Siripoon T., Charoenpong L., Soonthornworasiri N., Matsee W., Kittitrakul C., Tangkijvanich P., Charunwatthana P., Poovorawan K. Prevalence, Risk Factors, and Prognosis of Liver Involvement in Adult Patients with Chikungunya in Thailand. The American journal of tropical medicine and hygiene Vol.107 No.5 (2022) , 1107-1113. 1113. doi:10.4269/ajtmh.22-0339 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85376
Title
Prevalence, Risk Factors, and Prognosis of Liver Involvement in Adult Patients with Chikungunya in Thailand
Other Contributor(s)
Abstract
Chikungunya is a mosquito-borne disease mainly characterized by fever with polyarthralgia. Currently, liver complications of chikungunya remain rarely described. This study assesses the prevalence, severity, and risk factors of liver involvement, and the association between liver involvement severity and prognosis. We conducted a retrospective cohort study at two referral centers for tropical infectious diseases-the Hospital for Tropical Diseases and Bamrasnaradura Infectious Diseases Institute in Thailand-from January 2016 to April 2021. The study included 400 patients diagnosed with chikungunya. Of them, 254 (63.5%) were female with a mean age of 41.5 ± 14.1 years, and 98.5% of them presented with fever with arthralgia. Gastrointestinal presentations included nausea or vomiting (n = 62, 15.5%), diarrhea (n = 33, 8.3%), and abdominal pain (n = 4, 1%). Of 88 patients with available liver function tests, 39.8% had hepatitis (abnormal alanine aminotransferase levels), of whom 5.7% had moderate hepatitis. Nausea or vomiting is a clinical risk factor associated with liver involvement (adjusted odds ratio, 5.17; 95% CI, 1.20-22.34). Liver involvement was usually observed during the first 2 weeks of illness and resolved eventually. None of the patients experienced severe hepatitis, liver failure, or death caused by a liver problem. In conclusion, most of the patients with chikungunya did not have significant liver involvement. In those patients with severe liver injury, coexisting causes should be considered.