Prevalence of and factors independently associated with digital ischemic complications in patients with systemic sclerosis
Issued Date
2022-01-01
Resource Type
ISSN
23971983
eISSN
23971991
Scopus ID
2-s2.0-85136629042
Journal Title
Journal of Scleroderma and Related Disorders
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Scleroderma and Related Disorders (2022)
Suggested Citation
Guayboon T., Muangchan C. Prevalence of and factors independently associated with digital ischemic complications in patients with systemic sclerosis. Journal of Scleroderma and Related Disorders (2022). doi:10.1177/23971983221118720 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85046
Title
Prevalence of and factors independently associated with digital ischemic complications in patients with systemic sclerosis
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Objective: To investigate the prevalence of and independent predictors for digital ischemic complications in patients with systemic sclerosis. Method: Patients enrolled in the Siriraj Systemic Sclerosis Cohort registry during 2013–2019 were classified as having or not having digital ischemic complications at the baseline and 1-year timepoints. Results: A total of 171 patients with systemic sclerosis were included. The prevalence of digital pulp loss, digital pitting scar, digital ulcer, and digital amputation at baseline and 1 year was 41.5%, 39.8%, 3.5%, 7.6% and 37.4%, 43.9%, 14.1%, 6.4%, respectively. Over half (58.5%) of overall systemic sclerosis had developed new digital ischemic complications during the 1-year follow-up. Those with digital ischemic complications at baseline were at high risk for developing new digital ischemic complications (odds ratio: 15.9). Diffuse cutaneous systemic sclerosis is associated with digital ischemic complications (odds ratio: 6.0), digital pitting scar (odds ratio: 4.9), and digital pulp loss (odds ratio: 6.4). Tendon friction rub is associated with digital pitting scar (odds ratio: 5.0). Salt-and-pepper skin appearance is associated with digital pulp loss (odds ratio: 3.0) and digital ulcer (odds ratio: 6.9). Disease duration > 3 years is associated with digital ulcer (odds ratio: 4.4). Male gender is associated with digital ulcer (odds ratio: 5.4). Conclusion: Digital pulp loss, digital pitting scar, digital ulcer, and digital amputation were common manifestations of digital ischemic complications, and diffuse cutaneous systemic sclerosis was the strongest of the six independent predictors.