Comparison of Efficacy Between Thai Herbal Anti-hemorrhoid Formula and Micronized Purified Flavonoid Fraction in Patients with Internal Hemorrhoids
Issued Date
2024-01-01
Resource Type
ISSN
08574421
eISSN
2586940X
Scopus ID
2-s2.0-85212937980
Journal Title
Journal of Health Research
Volume
38
Issue
6
Start Page
519
End Page
528
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Health Research Vol.38 No.6 (2024) , 519-528
Suggested Citation
Rattanawongsamathakul D., Lohsiriwat V., Booranasubkajorn S., Apichartvorakit A., Akarasereenont P. Comparison of Efficacy Between Thai Herbal Anti-hemorrhoid Formula and Micronized Purified Flavonoid Fraction in Patients with Internal Hemorrhoids. Journal of Health Research Vol.38 No.6 (2024) , 519-528. 528. doi:10.56808/2586-940X.1110 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102599
Title
Comparison of Efficacy Between Thai Herbal Anti-hemorrhoid Formula and Micronized Purified Flavonoid Fraction in Patients with Internal Hemorrhoids
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Abstract
Background: Hemorrhoids are a common anorectal condition. In Thai traditional medicine, the Bantaoridsidwangthawan formula (BRF) has been used to treat hemorrhoids. We aimed to evaluate the clinical efficacy and satisfaction of BRF versus Micronized purified flavonoid fraction (MPFF) in patients with internal hemorrhoids grades 1 and 2. Methods: This was a single-blind, randomized control noninferiority trial. Twenty-seven participants were randomly assigned to BRF (n ¼ 13) or MPFF (n ¼ 14). The BRF group received 5 pills 3 times daily for 14 days. The MPFF group received 2 tablets 3 times daily for 4 days, and then 2 tablets 2 times daily for 6 days. The degree of hemorrhoid, bleeding, prolapse, severity of pain, and metabolomic profiling were recorded twice, once at baseline and once after treatment. Results: BRF group had better outcomes compared to that of the MPFF group in terms of hemorrhoid grade and bleeding severity. Both groups had decreased prolapse severity and reported equal satisfaction levels. Twenty-nine potential metabolites associated with anti-inflammatory and antioxidant properties were detected in both groups. Participants in both groups displayed neither abnormal liver nor kidney function. Conclusions: For internal hemorrhoids grades 1 and 2, BRF outperforms MPFF in terms of lowering both hemorrhoid grade and bleeding severity. However, BRF and MPFF there was not a difference between groups in terms of reducing the severity of pain. Further studies should be conducted to better understand the mechanism of action of BRF.