KIR copy number variations in dengue-infected patients from northeastern Thailand
1
Issued Date
2022-04-01
Resource Type
ISSN
01988859
eISSN
18791166
Scopus ID
2-s2.0-85123077231
Pubmed ID
35063258
Journal Title
Human Immunology
Volume
83
Issue
4
Start Page
328
End Page
334
Rights Holder(s)
SCOPUS
Bibliographic Citation
Human Immunology Vol.83 No.4 (2022) , 328-334
Suggested Citation
Chaisri S., Jayaraman J., Mongkolsapaya J., Duangchinda T., Jumniansong A., Trowsdale J., Traherne J.A., Leelayuwat C. KIR copy number variations in dengue-infected patients from northeastern Thailand. Human Immunology Vol.83 No.4 (2022) , 328-334. 334. doi:10.1016/j.humimm.2022.01.005 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85005
Title
KIR copy number variations in dengue-infected patients from northeastern Thailand
Other Contributor(s)
Abstract
Killer immunoglobulin-like receptors (KIRs) are a family of receptors expressed on Natural killer (NK) cells. The extensive polymorphism of KIR is involved in the immune responses of NK cells and influences dengue infections. We investigated the diversity of KIR copy numbers in dengue-infected patients from northeastern Thailand. Copy numbers of KIRs were determined by quantitative polymerase chain reaction in 137 dengue-infected patients, comprising 63 dengue fever (DF) and 74 dengue hemorrhagic fever (DHF). The distribution of KIRs was observed to be between 0 and 4 copies. The KIR AA genotype with heterozygous KIR2DS4D/WT was the most common in dengue patients, 25.4% DF and 23% DHF. Forty KIR profiles were determined in dengue patients, including 31 usual, 6 expanded, and 3 contracted profiles. Investigation of KIR copy number and dengue severity indicated that two copies of KIR2DL3 combined with HLA-C1C1 associated with an increased risk of DHF (OR 2.32, 95% CI 1.159–4.624, P = 0.016), whereas one copy of KIR2DL2 and KIR2DL3 together with HLA-C1C1 associated with a reduced risk of DHF (OR 0.17, 95% CI 0.058–0.482, P < 0.001). The outcomes of this study will contribute to the understanding of KIR complexity and innate immune responses in dengue infections.