Dissection of Neurochemical Pathways Across Complexity and Scale
Issued Date
2025-07-01
Resource Type
ISSN
00223042
eISSN
14714159
Scopus ID
2-s2.0-105011197552
Journal Title
Journal of Neurochemistry
Volume
169
Issue
7
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Neurochemistry Vol.169 No.7 (2025)
Suggested Citation
Abbondanza A., Kim N., Lima-Filho R.A.S., Amin A., Anversa R.G., Almeida F.B., Cardozo P.L., Carello-Collar G., Carsana E.V., Folarin R.O., Guerreiro S., Ijomone O.K., Lawal S.K., Matias I., Mbagwu S.I., Niño S.A., Olabiyi B.F., Olatunji S.Y., Olasehinde T.A., Ruankham W., Sanchez W.N., Soares-Cunha C., Soto P.A., Soto-Verdugo J., Strogulski N.R., Tomaszewska W., Vieira C., Chaves-Filho A., Cousin M.A., Rinken A., Wenzel T.J. Dissection of Neurochemical Pathways Across Complexity and Scale. Journal of Neurochemistry Vol.169 No.7 (2025). doi:10.1111/jnc.70160 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/111425
Title
Dissection of Neurochemical Pathways Across Complexity and Scale
Author(s)
Abbondanza A.
Kim N.
Lima-Filho R.A.S.
Amin A.
Anversa R.G.
Almeida F.B.
Cardozo P.L.
Carello-Collar G.
Carsana E.V.
Folarin R.O.
Guerreiro S.
Ijomone O.K.
Lawal S.K.
Matias I.
Mbagwu S.I.
Niño S.A.
Olabiyi B.F.
Olatunji S.Y.
Olasehinde T.A.
Ruankham W.
Sanchez W.N.
Soares-Cunha C.
Soto P.A.
Soto-Verdugo J.
Strogulski N.R.
Tomaszewska W.
Vieira C.
Chaves-Filho A.
Cousin M.A.
Rinken A.
Wenzel T.J.
Kim N.
Lima-Filho R.A.S.
Amin A.
Anversa R.G.
Almeida F.B.
Cardozo P.L.
Carello-Collar G.
Carsana E.V.
Folarin R.O.
Guerreiro S.
Ijomone O.K.
Lawal S.K.
Matias I.
Mbagwu S.I.
Niño S.A.
Olabiyi B.F.
Olatunji S.Y.
Olasehinde T.A.
Ruankham W.
Sanchez W.N.
Soares-Cunha C.
Soto P.A.
Soto-Verdugo J.
Strogulski N.R.
Tomaszewska W.
Vieira C.
Chaves-Filho A.
Cousin M.A.
Rinken A.
Wenzel T.J.
Author's Affiliation
University of Melbourne
Sorbonne Université
The University of Edinburgh
Università degli Studi di Milano
Universidade Federal do Rio de Janeiro
Universidade Federal do Rio Grande do Sul
Universidade Federal de Minas Gerais
Trinity College Dublin
Universidad de Chile
University of KwaZulu-Natal
Mahidol University
University of Victoria
Vanderbilt University School of Medicine
Universidade do Minho
VCU School of Medicine
Bergische Universität Wuppertal
Edinburgh Medical School
National Institute on Drug Abuse (NIDA)
University of Saskatchewan, College of Medicine
University of Botswana
The Babraham Institute
Universidade Federal de Ciencias da Saúde de Porto Alegre
Nencki Institute of Experimental Biology of the Polish Academy of Sciences
Nnamdi Azikiwe University
Institute of Physiology of the Academy of Sciences of the Czech Republic
Escola de Medicina da Universidade do Minho
Instituto de Química y Fisicoquímica Biológicas, Buenos Aires
Medizinischen Fakultät der Universität Bonn
University of Medical Sciences
Tartu Ülikooli Keemia Instituut
University of Global Health Equity
Łukasiewicz - PORT Polski Ośrodek Rozwoju Technologii
Centro de Gerociencia, Salud Mental y Metabolismo
Federal Institute of Industrial Research
Sorbonne Université
The University of Edinburgh
Università degli Studi di Milano
Universidade Federal do Rio de Janeiro
Universidade Federal do Rio Grande do Sul
Universidade Federal de Minas Gerais
Trinity College Dublin
Universidad de Chile
University of KwaZulu-Natal
Mahidol University
University of Victoria
Vanderbilt University School of Medicine
Universidade do Minho
VCU School of Medicine
Bergische Universität Wuppertal
Edinburgh Medical School
National Institute on Drug Abuse (NIDA)
University of Saskatchewan, College of Medicine
University of Botswana
The Babraham Institute
Universidade Federal de Ciencias da Saúde de Porto Alegre
Nencki Institute of Experimental Biology of the Polish Academy of Sciences
Nnamdi Azikiwe University
Institute of Physiology of the Academy of Sciences of the Czech Republic
Escola de Medicina da Universidade do Minho
Instituto de Química y Fisicoquímica Biológicas, Buenos Aires
Medizinischen Fakultät der Universität Bonn
University of Medical Sciences
Tartu Ülikooli Keemia Instituut
University of Global Health Equity
Łukasiewicz - PORT Polski Ośrodek Rozwoju Technologii
Centro de Gerociencia, Salud Mental y Metabolismo
Federal Institute of Industrial Research
Corresponding Author(s)
Other Contributor(s)
Abstract
The field of Neurochemistry spent decades trying to understand how the brain works, from nano to macroscale and across diverse species. Technological advancements over the years allowed researchers to better visualize and understand the cellular processes underpinning central nervous system (CNS) function. This review provides an overview of how novel models, and tools have allowed Neurochemistry researchers to investigate new and exciting research questions. We discuss the merits and demerits of different in vivo models (e.g., Caenorhabditis elegans, Drosophila melanogaster, Ratus norvegicus, and Mus musculus) as well as in vitro models (e.g., primary cells, induced pluripotent stem cells, and immortalized cells) to study Neurochemical events. We also discuss how these models can be paired with cutting-edge genetic manipulation (e.g., CRISPR-Cas9 and engineered viral vectors) and imaging techniques, such as super-resolution microscopy and new biosensors, to study cellular processes of the CNS. These technological advancements provide new insight into Neurochemical events in physiological and pathological contexts, paving the way for the development of new treatments (e.g., cell and gene therapies or small molecules) that aim to treat neurological disorders by reverting the CNS to its homeostatic state. (Figure presented.)