The prevalence of malnutrition in Thai patients with alzheimer's disease
5
Issued Date
2012
Copyright Date
2012
Resource Type
Language
eng
File Type
application/pdf
No. of Pages/File Size
ix, 64 leaves
Access Rights
open access
Rights
ผลงานนี้เป็นลิขสิทธิ์ของมหาวิทยาลัยมหิดล ขอสงวนไว้สำหรับเพื่อการศึกษาเท่านั้น ต้องอ้างอิงแหล่งที่มา ห้ามดัดแปลงเนื้อหา และห้ามนำไปใช้เพื่อการค้า
Rights Holder(s)
Mahidol University
Bibliographic Citation
Thesis (M.Sc. (Food and Nutrition for Development))--Mahidol University, 2012
Suggested Citation
Sopacha Jiamrungraksa The prevalence of malnutrition in Thai patients with alzheimer's disease. Thesis (M.Sc. (Food and Nutrition for Development))--Mahidol University, 2012. Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/95129
Title
The prevalence of malnutrition in Thai patients with alzheimer's disease
Alternative Title(s)
ความชุกของภาวะทุพโภชนาการในผู้ป่วยไทยที่เป็นโรคสมองเสื่อมชนิดอัลไซเมอร์
Author(s)
Abstract
Patients with Alzheimer's disease (AD) may have an increased risk for malnutrition, due to decline in cognition, loss of ability to help themselves, eating disorders and neuropsychological symptoms. Previous studies found that AD patients are associated with vitamin deficiencies. However, the relationship between the nutritional status and the stage of dementia in the elderly is still unclear. The objectives of this study were 1) to determine the nutritional status among Thai AD patients 2) to determine the relationship between nutritional status, vitamin and antioxidant levels, and stages of Alzheimer's disease 3) to determine the prevalence of malnutrition and stages of Alzheimer's disease. A cross-sectional study of 136 Thai AD patients in memory and geriatric outpatient clinics was conducted at Ramathibodi Hospital. The dementia severity was categorized into three levels - mild, moderate, and severe - according to the Global Deterioration Scale (GDS). Nutritional status was assessed by the Mini Nutritional Assessment (MNA), anthropometric measurements [body mass index (BMI), waist circumference, and bioelectrical impedance analysis (BIA)]. Blood biochemical analysis included general (Hb, Hct, serum albumin, FBS and lipid profiles; total cholesterol, HDL-C, LDL-C and TG) and specific (vitamin A, B1, B12, C, E, beta-carotene and folate) determinants of clinical and nutritional status. Mean age of study patients was 78.08 ± 7.47 years. 77.9% were female. According to the MNA classification, 50% of severe group were malnourished. An increased risk of malnutrition was also found in moderate group (57.8%). The mean MNA in the severe group was significant lower than those in the mild and the moderate groups (P<0.05). There was no significant difference between groups in anthropometric measurements. The severe group was more prominent in the underweight (31%), whereas overweight was found in mild group (45.6%). More than 50% of every stage of dementia were present with abdominal obesity. Most of blood biochemical analyses were within the reference ranges. However the differences between groups were not found. Hb, Hct and serum Alb levels in the severe group were significantly different from the mild and the moderate group (p < 0.05). From the 24hr-recall dietary assessment, there were no significant differences in energy and nutrient intakes between groups. In this study, most presented a nutritional status of malnourished in severe groups. This study demonstrates the current and limited data of nutritional status both in underweight and overweight in Thai AD patients with some significant clinical markers in the severe group. The findings of high levels of vitamins were necessary to verify in order to create an overall nutritional strategy for AD treatment. Because malnutrition is a common problem in AD patients, some strategies can be adopted to improve the nutritional status of these patients. These strategies include patient and caregiver nutritional education programs, and the use of oral nutritional supplements, which can significantly impact nutritional status by reducing the prevalence of malnutrition in AD patients. Therefore, more studies are needed to be done in this area in the future.
Description
Food and Nutrition for Development (Mahidol University 2012)
Degree Name
Master of Science
Degree Level
Master's degree
Degree Department
Institute of Nutrition
Degree Discipline
Food and Nutrition for Development
Degree Grantor(s)
Mahidol University