AgSCN/(NH4)2S2O8-Promoted Cascade Cyclization of 1-(2-Ethynylphenyl)-1H-indoles and Derivatives
4
Issued Date
2025-10-10
Resource Type
ISSN
00223263
eISSN
15206904
Scopus ID
2-s2.0-105018456629
Journal Title
Journal of Organic Chemistry
Volume
90
Issue
40
Start Page
14057
End Page
14065
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Organic Chemistry Vol.90 No.40 (2025) , 14057-14065
Suggested Citation
Hassa N., Punnita S., Uppalabat T., La-ongthong K., Sawektreeratana N., Janthakit P., Nalaoh P., Promarak V., Leowanawat P., Soorukram D., Reutrakul V., Katrun P., Bunchuay T., Kuhakarn C. AgSCN/(NH4)2S2O8-Promoted Cascade Cyclization of 1-(2-Ethynylphenyl)-1H-indoles and Derivatives. Journal of Organic Chemistry Vol.90 No.40 (2025) , 14057-14065. 14065. doi:10.1021/acs.joc.5c01202 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112671
Title
AgSCN/(NH4)2S2O8-Promoted Cascade Cyclization of 1-(2-Ethynylphenyl)-1H-indoles and Derivatives
Corresponding Author(s)
Other Contributor(s)
Abstract
Described herein is an efficient and novel method for the synthesis of 6-arylindolo[1,2-a]quinoline-5,7-diones from 1-(2-ethynylphenyl)-1H-indoles. The reaction readily proceeded via a tandem process, leading to the desired products in moderate yields. The reaction can accommodate a broad range of functional groups and is efficient on a gram-scale synthesis. Under standard reaction conditions, 4-phenylpyrrolo[1,2-a]quinoline-3,5-dione can be readily accessed by using 1-(2-(phenylethynyl)phenyl)-1H-pyrrole as a substrate. The single-crystal X-ray diffraction data confirm the chemical structure of the product. Photophysical properties of some selected 6-arylindolo[1,2-a]quinoline-5,7-diones were studied by UV–visible and fluorescence spectroscopy.