A systematic review and meta-analysis of changes in interleukin-8 levels in malaria infection
Issued Date
2023-09-01
Resource Type
ISSN
10434666
eISSN
10960023
Scopus ID
2-s2.0-85162094640
Pubmed ID
37327530
Journal Title
Cytokine
Volume
169
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cytokine Vol.169 (2023)
Suggested Citation
Kotepui M., Mala W., Kwankaew P., Mahittikorn A., Ramirez Masangkay F., Uthaisar Kotepui K. A systematic review and meta-analysis of changes in interleukin-8 levels in malaria infection. Cytokine Vol.169 (2023). doi:10.1016/j.cyto.2023.156262 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87664
Title
A systematic review and meta-analysis of changes in interleukin-8 levels in malaria infection
Other Contributor(s)
Abstract
The roles of interleukin-8 (IL-8) in malaria are inconsistent and unclear. This study synthesised evidence for differences in IL-8 levels in patients with malaria of various levels of severity. Relevant studies were searched in Scopus, MEDLINE, Embase, CENTRAL and PubMed from inception to 22 April 2022. Pooled mean differences (MDs) and 95% confidence intervals (CIs) were estimated using the random effects model. Of 1083 articles retrieved from the databases, 34 were included for syntheses. The meta-analysis revealed increased IL-8 levels in individuals with uncomplicated malaria compared with those without malaria (P = 0.04; MD, 25.57 pg/mL; 95% CI, 1.70 to 49.43 pg/mL; I2, 99.53, 4 studies; 400 uncomplicated malaria, 204 uninfected controls). The meta-analysis revealed comparable levels of IL-8 between the two groups (P = 0.10; MD, 74.46 pg/mL; 95% CI, −15.08 to 164.0 pg/mL; I2, 9.03; 4 studies; 133 severe malaria cases, 568 uncomplicated malaria cases). The study found evidence of increased IL-8 levels in individuals with malaria compared with those without malaria. However, no differences were found in IL-8 levels between patients with severe and non-severe malaria. Further research is needed to investigate the IL-8 cytokine levels in patients with malaria of different levels of severity.